Sulfadiazine sodium |
![]() Last updated: 14/09/2025 |
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(Also known as: sodium sulfadiazine; sulfadiazin-natrium) |
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A commonly used synthetically produced livestock antibiotic / antimicrobial with antiparasitic properties | |
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Multiple uses including bladder and prostate infections, Nocardia infections, or parasitic infections | |
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Dogs; Cats; Horses, Cattle; Poultry; Pigs |
Approval status |
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Approved - usually supplied as a prescription only medicine to be authorised by a veterinarian (POM-V) | |
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Approved |
Chemical structure |
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None | |
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C₁₀H₉N₄NaO₂S | |
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C1=CN=C(N=C1)[N-]S(=O)(=O)C2=CC=C(C=C2)N.[Na+] | |
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JLDCNMJPBBKAHH-UHFFFAOYSA-N | |
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InChI=1S/C10H9N4O2S.Na/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1 | |
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Yes |
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Common Name | Relationship | Link |
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sulfadiazine sodium | Parent | ![]() |
General status |
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Antiparasitic, Antibacterial, Coccidiostat, Antiprotozoal | |
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Sulfonamide | |
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Synthetic | |
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Inhibits the production of folic acid necessary for the growth and multiplication of bacteria | |
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[Dihydropteroate synthetase, Antagonist] | |
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547-32-0 | |
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208-919-0 | |
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15899898 | |
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Antiinfectants for systemic use: Antibacterials for systemic use | |
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QJ01EW10 | |
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No | |
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Allowed substance (Table 1: All food producing species) | |
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272.26 | |
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sodium;(4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide | |
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Potential groundwater pollutant | |
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Commercial |
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Current | |||
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Circa 1935, discovered | |||
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Usually supplied as tablets, oral solutions or in formulations for preparation as injection solutions | |||
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The production of sulfadiazine sodium begins with the base compound sulfadiazine, which is synthesised through the condensation of sulfanilamide with 2-aminopyrimidine under controlled conditions. To form the sodium salt, sulfadiazine is dissolved in a mixture of water and ethanol, and then reacted with sodium hydroxide to neutralise the sulfonamide group, yielding sulfadiazine sodium. The solution is heated and stirred until fully dissolved, then cooled to promote crystallisation. | |||
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Published GHG data is not available for most pharmaceuticals. However, according to industry, global averages suggest producing 1 kg of a typical active pharmaceutical ingredient can range from 10 to 100 kg CO₂e for small molecule drugs and potentially up to 1000 kg CO₂e for complex biologicals such as vaccines, depending on the drug type, its formulation, complexity of synthesis, solvent recovery, and energy sources used. |
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Substance may enter the environment via the urine and faeces of treated animals. Monitoring studies have identified this substance in pig, cattle and poultry manure. |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Fate indices |
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Known soil and groundwater metabolites |
None
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N4-acetyl-sulfadiazine | Ac-SDZ | Animals (Urine) | - |
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Terrestrial ecotoxicology |
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1500 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Mouse4 = Verified data |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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1500 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Mouse4 = Verified data |
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Largely excreted in the urine | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Possible kidney and renal system toxicant |
Handling issues |
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IMDG Transport Hazard Class 6.1 | |||
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Not listed (Not listed) | |||
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Packaging Group III (minor danger) | |||
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sulfadiazine sodium | ||
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Record last updated: | 14/09/2025 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |