Sulfadiazine sodium |
Last updated: 20/03/2024 |
(Also known as: sodium sulfadiazine; sulfadiazin-natrium) |
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A commonly used synthetically produced livestock antibiotic / antimicrobial with antiparasitic properties | |
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Current | |
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circa 1935, discovered | |
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Multiple uses including bladder and prostate infections, Nocardia infections, or parasitic infections | |
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Dogs; Cats; Horses, Cattle; Poultry; Pigs |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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C₁₀H₉N₄NaO₂S | |
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C1=CN=C(N=C1)[N-]S(=O)(=O)C2=CC=C(C=C2)N.[Na+] | |
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JLDCNMJPBBKAHH-UHFFFAOYSA-N | |
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InChI=1S/C10H9N4O2S.Na/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1 | |
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Yes |
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Common Name | Relationship | Link |
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sulfadiazine sodium | Parent |
General status |
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Antiparasitic, Antibacterial, Coccidiostat, Antiprotozoal | |
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Sulfonamide | |
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Synthetic | |
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Inhibits the production of folic acid necessary for the growth and multiplication of bacteria | |
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[Dihydropteroate synthetase, Antagonist] | |
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547-32-0 | |
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208-919-0 | |
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15899898 | |
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Antiinfectants for systemic use: Antibacterials for systemic use | |
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QJ01EW10 | |
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No | |
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Allowed substance (Table 1: All food producing species) | |
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272.26 | |
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sodium;(4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide | |
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Potential groundwater pollutant | |
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Formulations |
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Formulated in a variety of different products including medicated feeds, oral pastes, solutions for injection and oral suspensions |
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Substance may enter the environment via the urine and faeces of treated animals. Monitoring studies have identified this substance in pig, cattle and poultry manure. |
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17 | R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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N4-acetyl-sulfadiazine | Ac-SDZ | Animals (Urine) | - |
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Terrestrial ecotoxicology |
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1500 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Mouse4 = Verified data |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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1500 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Mouse4 = Verified data |
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Largely excreted in the urine | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Possible kidney and renal system toxicant |
Handling issues |
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IMDG Transport Hazard Class 6.1 | |||
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Not listed (Not listed) | |||
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Packaging Group III (minor danger) | |||
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sulfadiazine sodium | ||
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Record last updated: | 20/03/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |