Danofloxacin mesylate |
Last updated: 18/05/2024 |
(Not known by any other names) |
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A synthetic fluoroquinolone broad spectrum antibacterial and antimicrobial veterinary treatment | |
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Current | |
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Used to control nfections of the respiratory tract and intestinal tract including bovine respiratory disease associated with Mannheimia (Pasteurella) haemolytica and Pasteurella multocida | |
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Cattle; Pigs; Domestic fowl |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₂₀H₂₄FN₃O₆S | |
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CN1CC2CC1CN2C3=C(C=C4C(=C3)N(C=C(C4=O)C(=O)O)C5CC5)F.CS(=O)(=O)O | |
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CN1C[C@@H]2C[C@H]1CN2C3=C(C=C4C(=C3)N(C=C(C4=O)C(=O)O)C5CC5)F.CS(=O)(=O)O | |
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APFDJSVKQNSTKF-FXMYHANSSA-N | |
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InChI=1S/C19H20FN3O3.CH4O3S/c1-21-7-12-4-11(21)8-22(12)17-6-16-13(5-15(17)20)18(24)14(19(25)26)9-23(16)10-2-3-10;1-5(2,3)4/h5-6,9-12H,2-4,7-8H2,1H3,(H,25,26);1H3,(H,2,3,4)/t11-,12-;/m0./s1 | |
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Yes |
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Common Name | Relationship | Link |
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danafoxacin dihydrate | Parent hydrate |
General status |
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Antibacterial, Antimicrobial | |
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Fluoroquinolone | |
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Synthetic | |
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Inhibits DNA gyrase and triggers induction of the SOS response and temperate bacteriophages | |
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[DNA gyrase subunit A, Antagonist] | |
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119478-55-6 | |
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Antiinfectants for systemic use: Antibacterials for systemic use | |
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QJ01MA92 | |
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No | |
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Allowed substance (Table 1: All food producing species) | |
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453.48 | |
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(1S)-1-cyclopropyl-6-fluoro-1,4-dihydro-7-(5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl)-4-oxo-3-quinoline carboxylic acid methanesulphonate | |
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White to off-white crystalline powder | |
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Formulations |
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Advocin 180 mg/ml Solution for Injection for Cattle | Zeotis UK Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Advosin 2.5% solution for Injection | Zeotis UK Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Usually formulated as a solution for injection |
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65.6 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Moderate | ||||||||
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100 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Ethanol3 = Unverified data of known source |
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100 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Acetone3 = Unverified data of known source |
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328 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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2.45 X 1000 | Calculated | - | |||||||
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0.39 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Low | ||||||||
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6.22 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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PKa(2)=9.43 | |||||||||||
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pH 5: 208nm=12090, 234nm=8553, 282nm=47796, 310nm=9957, 350nm=10682 pH7: 234nm=10612, 276nm=43268, 336nm=13244 pH9: 234nm=11392, 277nm=41978, 328nm=13877 |
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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Released intermittently into the environment via faeces and urine of medicated animals as well as via the spreading of manure |
Degradation |
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115 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Persistent | |||||||
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Literature values DT₅₀ range 87-143 mL g⁻¹ | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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2837 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
Non-mobile | |||||||
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284533 | ||||||||||
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USEPA data Kd range 2280-3800 mL g⁻¹, Koc range 75600-644000 mL g⁻¹, Soils=3; Data for faecal adsorption; Kd range 138-541 mL g⁻¹, Koc range 323-1036 mL g⁻¹ | ||||||||||
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Fate indices |
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-3.00 | Calculated | Low leachability | ||||||||||||||||||||||||||
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16 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Low potential | |||||||||||||||||||||||||
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ND | - |
Known soil and groundwater metabolites |
None
Other known metabolites |
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N-desmethyldanofloxacin | - | Cattle | - |
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Terrestrial ecotoxicology |
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> 2000 | R3 R = Peer reviewed scientific publications Rat3 = Unverified data of known source |
Low | ||||||||
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> 1200 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Lumbricus terrestris3 = Unverified data of known source |
Low | ||||||||
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> 1000 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Corn Soybean Cucumber Wheat Pinto bean3 = Unverified data of known source Seedling emergence, NOEC as mg kg⁻¹ |
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Aquatic ecotoxicology |
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> 100 | R3 R = Peer reviewed scientific publications Cyprinodon variegatus marine species3 = Unverified data of known source |
Low | ||||||||
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> 63.5 | R3 R = Peer reviewed scientific publications Daphnia magna3 = Unverified data of known source |
Moderate | ||||||||
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> 100 | R3 R = Peer reviewed scientific publications Americamysis bahia3 = Unverified data of known source |
Low | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 2000 | R3 R = Peer reviewed scientific publications Rat3 = Unverified data of known source |
Low | ||||||||
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In rats, dogs and pigs it is excreted in the unchanged form in the urine | V4 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 4 = Verified data |
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Health issues |
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May cause gastrointestinal problems |
Handling issues |
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Not compatible with oxidising agents May emit hamful gases when heated |
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Health: H373 Environment: H412 |
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Not listed (Not listed) | |||
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danofloxacin mesylate | ||
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mesilate de danofloxacine | ||
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mesilato de danofloxacino | ||
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mesilato de danofloxacino | ||
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Record last updated: | 18/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |