Danofloxacin |
Last updated: 22/05/2024 |
(Not known by any other names) |
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A synthetic fluoroquinolone broad spectrum antibacterial and antimicrobial veterinary treatment active against both gram-positive and gram-negative bacteria | |
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Current | |
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circa 2000, introduced | |
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Used to control nfections of the respiratory tract and intestinal tract including bovine respiratory disease associated with Mannheimia (Pasteurella) haemolytica and Pasteurella multocida | |
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Cattle; Pigs; Domestic fowl |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₁₉H₂₀FN₃O₃ | |
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CN1CC2CC1CN2C3=C(C=C4C(=C3)N(C=C(C4=O)C(=O)O)C5CC5)F | |
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CN1C[C@@H]2C[C@H]1CN2C3=C(C=C4C(=C3)N(C=C(C4=O)C(=O)O)C5CC5)F | |
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QMLVECGLEOSESV-RYUDHWBXSA-N | |
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InChI=1S/C19H20FN3O3/c1-21-7-12-4-11(21)8-22(12)17-6-16-13(5-15(17)20)18(24)14(19(25)26)9-23(16)10-2-3-10/h5-6,9-12H,2-4,7-8H2,1H3,(H,25,26)/t11-,12-/m0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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danofloxacin dihydrate | Hydrate |
General status |
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Antibacterial, Antimicrobial | |
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Fluoroquinolone drug | |
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Synthetic | |
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Inhibits DNA gyrase and triggers induction of the SOS response and temperate bacteriophages | |
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[DNA gyrase subunit A, Antagonist] | |
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112398-08-0 | |
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638-772-1 | |
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71335 | |
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Antiinfectants for systemic use: Antibacterials for systemic use | |
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QJ01MA92 | |
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No | |
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Allowed substance (Table 1: All food producing species) | |
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357.37 | |
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1-cyclopropyl-6-fluoro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-4-oxoquinoline-3-carboxylic acid | |
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Formulations |
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Usually formulated as a solution for injection |
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263 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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Released intermittently into the environment via faeces and urine of medicated animals as well as via the spreading of manure |
Degradation |
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115 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Persistent | |||||||
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US EPA data gives DT₅₀ range 91-143 days, Soils=3 | ||||||||||
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0.003 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Fast | |||||||
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Very rapid: 4.3 minutes at pH 7 | ||||||||||
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Stable | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
Stable | |||||||
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Stable at pH 5-9 | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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2837 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) as mesylate variant3 = Unverified data of known source |
Non-mobile | |||||||
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284533 | ||||||||||
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Kd range 2280-3800 mL g⁻¹, Kfoc range 75699-644000 mL g⁻¹, Soils=3; Data for faecal adsorption; Kd range 138-541 mL g⁻¹, Koc range 323-1036 mL g⁻¹ | ||||||||||
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Fate indices |
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-3.00 | Calculated | Low leachability | ||||||||||||||||||||||||||
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Known soil metabolites |
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Known groundwater metabolites |
None
Other known metabolites |
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N-desmethyldanofloxacin | - | Cattle | - |
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Terrestrial ecotoxicology |
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> 2000 | R3 R = Peer reviewed scientific publications Rat3 = Unverified data of known source |
Low | ||||||||
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> 1200 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Lumbricus terrestris as mesylate3 = Unverified data of known source |
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> 1000 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Corn Soybean Cucumber Wheat Pinto bean3 = Unverified data of known source Seedling emergence, NOEC as mg kg⁻¹ of mesylate |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 2000 | R3 R = Peer reviewed scientific publications Rat3 = Unverified data of known source |
Low | ||||||||
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5000 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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> 10.0 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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Intravenous LD₅₀ = 75 mg l⁻¹ | Q3 Q = Miscellaneous data from online sources Mouse3 = Unverified data of known source |
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In rats, dogs and pigs it is excreted in the unchanged form in the urine | V4 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 4 = Verified data |
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Health issues |
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May cause gastrointestinal problems |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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danofloxacin | ||
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danofloxacine | ||
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danofloxacino | ||
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danofloxacino | ||
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Record last updated: | 22/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |