Clorsulon (Ref: MK-401) |
Last updated: 23/02/2024 |
(Also known as: MK-0401; L-631529) |
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A benzenesulphonamide veterinary medication usually used in combination with ivermectin | |
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Current | |
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1985, first registered in USA | |
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Used to control adult liver flukes in cattle, sheep and other livestock. Also used on domestic pets. | |
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Domestic pets; Farm livestock particularly cattle, sheep |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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None | |
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C₈H₈Cl₃N₃O₄S₂ | |
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C1=C(C(=CC(=C1N)S(=O)(=O)N)S(=O)(=O)N)C(=C(Cl)Cl)Cl | |
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No data | |
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QOVTVIYTBRHADL-UHFFFAOYSA-N | |
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InChI=1S/C8H8Cl3N3O4S2/c9-7(8(10)11)3-1-4(12)6(20(14,17)18)2-5(3)19(13,15)16/h1-2H,12H2,(H2,13,15,16)(H2,14,17,18) | |
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Yes |
General status |
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Antiparasitic | |
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Sulphonamide | |
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- | |
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- | |
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Synthetic | |
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Inhibits the enzymes phosphoglycerate kinase and phosphoglyceromutase | |
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[Phosphoglycerate kinase, Inhibitor], [ Phosphoglyceromutase enzyme, Inhibitor] | |
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60200-06-8 | |
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262-100-2 | |
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- | |
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- | |
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- | |
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Antiparasitic products, insecticides & repellents: Endectocides | |
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QP54AA51 | |
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No | |
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- | |
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380.66 | |
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- | |
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4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide | |
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4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide | |
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- | |
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- | |
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White to off-white crystalline powder | |
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Formulations |
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Animec Super Solution for Cattle Injection | Chanelle Animal Health Ltd | GB National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | ||||||
Ivomac Super Solution for Cattle Injection | Boehringer Ingelheim Animal Health UK Ltd | UK National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
Virbamec Super Solution for Injection | Virbac Ltd | UK National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
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Often formulated in combination with ivermectin as a solution for injection |
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800 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
High | ||||||||
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17050 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) DMSO3 = Unverified data of known source |
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7000 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Ethanol3 = Unverified data of known source |
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203 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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205 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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348 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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1.51 X 1001 | Calculated | - | |||||||
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1.18 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
Low | ||||||||
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1.0 X 10-13 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Low volatility | ||||||||
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- |
Degradation |
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19.6 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Non-persistent | |||||||
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32.2 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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1.40 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Mobile | |||||||
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30.8 | ||||||||||
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- | ||||||||||
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1.57 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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1.06 | ||||||||||
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Fate indices |
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3.25 | Calculated | High leachability | ||||||||||||||||||||||||||
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 10000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Low | ||||||||
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1000 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Eisenia foetida4 = Verified data |
Moderate | ||||||||
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1031 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Oats3 = Unverified data of known source Shoot biomass, EC₅₀ as mg kg⁻¹ soil |
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212 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Corn3 = Unverified data of known source Shoot biomass, EC₅₀ as mg kg⁻¹ soil |
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Aquatic ecotoxicology |
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560 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Poecilia reticulata4 = Verified data |
Low | ||||||||
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1144 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna4 = Verified data |
Low | ||||||||
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56 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna4 = Verified data |
Low | ||||||||
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570 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Selenastrum capricornutum4 = Verified data |
Low | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 10000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Low | ||||||||
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Intraperitoneal LD₅₀ = 808 mg kg⁻¹ | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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0.002 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Dog SF=10004 = Verified data |
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Rapidly excreted in the faeces of animals | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Possible thyroid and liver toxicant Weak evidence to suggest substance is carcinogenic |
Handling issues |
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No information available | |||
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Human: H319, H373 | |||
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Not listed (Not listed) | |||
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Not regulated | |||
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Stable > 4 yrs; Not highly reactive |
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clorsulon | ||
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clorsulone | ||
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clorsulon | ||
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Record last updated: | 23/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |