Fenbendazole (Ref: Hoe 881v) |
Last updated: 02/02/2024 |
(Also known as: phenbendasol) |
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A broad spectrum benzimidazole anthelmintic used widely in veterinary medicine | |
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Current | |
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Used against gastrointestinal parasites in livestock, exotic animals and domestic pets | |
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Cattle; Sheep; Horses; Domestic pets; Hedgehogs; Bears; Elephants; Pigeons; Exotic birds; Ferrets; Fish |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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- | |
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C₁₅H₁₃N₃O₂S | |
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COC(=O)NC1=NC2=C(N1)C=C(C=C2)SC3=CC=CC=C3 | |
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No data | |
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HDDSHPAODJUKPD-UHFFFAOYSA-N | |
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InChI=1S/C15H13N3O2S/c1-20-15(19)18-14-16-12-8-7-11(9-13(12)17-14)21-10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19) | |
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Yes |
General status |
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Anthelmintic, Antiparasitic, Nematicide | |
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Benzimidazole | |
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Synthetic | |
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Binds to tubulin, a protein required for functions including nutrient uptake, thus disrupting parasite energy metabolism | |
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[Tubulin alpha-3 chain, Antagonist] | |
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43210-67-9 | |
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256-145-7 | |
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Antiparasitic products, insecticides & repellents: Anthelmintics | |
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QP52AC13 | |
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No | |
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Allowed substance (Table 1: Ruminants, Porcine, Equidae) | |
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299.35 | |
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methyl N-(6-phenylsulfanyl-1H-benzoimidazol-2-yl)carbamate | |
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2-(methoxycarbonylamino)-5-(phenylthio)benzimidazole | |
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White to dirty white coloured crystalline powder |
Formulations |
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Beaphar Worming Granules for Cats & Kittens | Sinclair Animal & Household Care Ltd | UK National authorisation (IC) | Authorised veterinary medicine for general sale (AVM-GSL) | ||||||
Curofen Oral Powder | Univet Ltd | GB National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
Granofen Wormer Granules | Viurbac Ltd | UK National authorisation | For non-food animal use and may be supplied without a prescription by a suitable qualified person (NFA-VPS) | |||||||
Zerofen Equine Granules | Chanelle Animal Health Ltd | UK National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
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Available in a variety of orally administered formulations including oral powders, medicated fereds annd products for adding to drinking water |
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0.01 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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233 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Decomposes on melting | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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7.08 X 1003 | Calculated | - | |||||||
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3.85 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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1.40 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Max absorption at 296nm | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Degradation |
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0.53 | V4 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 4 = Verified data |
Fast | |||||||
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Slight variation with pH: 0.71 days at pH5 & 0.47 days at pH9 | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | R4 R = Peer reviewed scientific publications 4 = Verified data |
Mobile | |||||||
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46 | ||||||||||
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General literature states Koc range 35-57 mL g⁻¹ | ||||||||||
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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oxfendazole (Ref: HOE 8105) | - | - | - |
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Terrestrial ecotoxicology |
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> 10000 | V4 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat4 = Verified data |
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1068 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Eisenia foetida4 = Verified data |
Low | ||||||||
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Aquatic ecotoxicology |
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0.04 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Oncorhynchus mykiss3 = Unverified data of known source |
High | ||||||||
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> 0.021 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Danio rerio EC₅₀ Embryo3 = Unverified data of known source |
High | ||||||||
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0.0165 | R4 R = Peer reviewed scientific publications Daphnia magna4 = Verified data |
High | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 10000 | V4 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat4 = Verified data |
Low | ||||||||
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Intraperitoneal LD₅₀ > 1250 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Subcutaneous LD₅₀ > 2000 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Slow adsorption, excreted mainly unchanged in the faeces | Q4 Q = Miscellaneous data from online sources 4 = Verified data |
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Health issues |
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No further information available |
Handling issues |
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Light sensitive | |||
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Not listed (Not listed) | |||
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fenbendazole | ||
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fenbendazole | ||
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fenbendazol | ||
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Record last updated: | 02/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |