Toltrazuril |
Last updated: 28/05/2024 |
(Also known as: TZR) |
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A broad-spectrum anticoccidial and antiprotozoal activity used to treat a variety of animals and poultry | |
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Current | |
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Used as a coccidiostat against coccidia and for canine Isospora infections | |
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Chickens; Turkeys; Cattle; Rabbits; Pigs |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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C₁₈H₁₄F₃N₃O₄S | |
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CC1=C(C=CC(=C1)N2C(=O)NC(=O)N(C2=O)C)OC3=CC=C(C=C3)SC(F)(F)F | |
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No data | |
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OCINXEZVIIVXFU-UHFFFAOYSA-N | |
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InChI=1S/C18H14F3N3O4S/c1-10-9-11(24-16(26)22-15(25)23(2)17(24)27)3-8-14(10)28-12-4-6-13(7-5-12)29-18(19,20)21/h3-9H,1-2H3,(H,22,25,26) | |
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Yes |
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Common Name | Relationship | Link |
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toltrazuril | - |
General status |
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Coccidiostat, Antiparasitic, Antiprotozoal | |
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Triazinetrione | |
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Synthetic | |
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Coccidiostat - damages all cell development of the Coccidia | |
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69004-03-1 | |
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Antiparasitic products, insecticides & repellents: Antiprotozoals | |
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QP51AJ01 | |
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No | |
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Allowed substance (Table 1: All mammalian food producing species, Polutry) | |
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425.38 | |
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1-methyl-3-(3-methyl-4-(4-((trifluoromethyl)thio)phenoxy)phenyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione | |
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Colourless to brown liquid |
Formulations |
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Baycox 2.5% Oral Solution | Elanco Europe Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Chanox Oral Suspension | Chanelle Pharmaceuticals Manufacturing Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Toltramax Oral Suspension | Lavet Pharmaceuticals Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Available in a variety of formulations including oral suspensions, solutions for drinking water and suspensions for injection |
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Miscible | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
Miscible | ||||||||
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194 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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180 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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1.51 X 1004 | Calculated | - | |||||||
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4.18 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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toltrazuril sulfoxide | TZR.SO; | Animals | - | ||||
ponazuril (Ref: Bay Vi 9143) | ponazuril | Animals | - |
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Terrestrial ecotoxicology |
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> 2000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Low | ||||||||
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700 | E3 E = Manufacturers safety data sheets Gallus domesticus3 = Unverified data of known source |
Moderate | ||||||||
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52 | E3 E = Manufacturers safety data sheets Eisenia foetida3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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> 2.0 | E3 E = Manufacturers safety data sheets Daphnia magna3 = Unverified data of known source |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 2000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Low | ||||||||
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5000 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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> 158 | E3 E = Manufacturers safety data sheets Rat 4 hr3 = Unverified data of known source |
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0.002 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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Majority excreted via the faeces, <10% via the urine. Circa 90% cleared in first 160hrs after dosage | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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No further information available |
Handling issues |
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Use carbon dioxide, dry chemical powder, appropriate foam or water to fight fires Emits toxic fumes under fire conditions Avoid strong oxidising agents |
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Not listed (Not listed) | |||
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toltrazuril | ||
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toltrazuril | ||
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toltrazurilo | ||
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Record last updated: | 28/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |