Ponazuril (Ref: Bay Vi 9143) |
Last updated: 11/01/2024 |
(Also known as: Toltrazuril sulfone) |
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A medicinal triazine-based veterinary drug used as antiprotozoal treatment | |
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Used to treat protozoal myeloencephalitis (EPM), caused by Sarcocystis neurona and various other parasitic conditions including coccidia | |
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Horses; Cats; Dogs; Piglets; Cattle; Goats; Llamas |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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The active metabolite of toltrazuril | |
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C₁₈H₁₄F₃N₃O₆S | |
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CC1=C(C=CC(=C1)N2C(=O)NC(=O)N(C2=O)C)OC3=CC=C(C=C3)S(=O)(=O)C(F)(F)F | |
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No data | |
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VBUNOIXRZNJNAD-UHFFFAOYSA-N | |
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InChI=1S/C18H14F3N3O6S/c1-10-9-11(24-16(26)22-15(25)23(2)17(24)27)3-8-14(10)30-12-4-6-13(7-5-12)31(28,29)18(19,20)21/h3-9H,1-2H3,(H,22,25,26) | |
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Yes |
General status |
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Coccidiostat, Antiparasitic, Antiprotozoal | |
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Triazinetrione | |
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>95% | |
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Synthetic | |
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Acts by inhibiting mitochondrial respirayion and nuclear pyrimidine synthesis in the parasite | |
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[Mitochondrial respiration, Inhibitor] | |
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69004-04-2 | |
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Antiprotozoals: Triazines | |
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QP51AJ04 | |
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No | |
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457.38 | |
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1-methyl-3-(3-methyl-4-(4-(trifluoromethylsulfonyl)phenoxy)phenyl)-1,3,5-triazinane-2,4,6-trione | |
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1-methyl-3-(3-methyl-4-(4-(trifluoromethylsulfonyl)phenoxy)phenyl)-1,3,5-triazinane-2,4,6-trione | |
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Off-white coloured powder | |
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Formulations |
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Marquis | Bayer Corporation | Not licensed | Not licensed | ||||||
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93.3 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Degradation |
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500 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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General literature cites the subtsance as being highly persistent with a DT₅₀ of > 1 year | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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980 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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General |
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980 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
Moderate | ||||||||
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Eliminated via the faeces | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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Health issues |
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May cause gastro-intestinal disturbance including vomiting and diarrhoea |
Handling issues |
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Not explosive Incompatible with oxidising agents Will emit toxic gases when heated to decomposition including hydrocyanic acid and hydrogen fluoride |
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Not listed (Not listed) | |||
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None allocated | |||
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|
ponazuril | ||
|
ponazuril | ||
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Ponazuril | ||
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Ponazurilo | ||
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Record last updated: | 11/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |