Ciprofloxacin (Ref: BRN 3568352) |
Last updated: 18/05/2024 |
(Not known by any other names) |
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A systemic fluoroquinolone antibiotic, usually used as an alternative to enrofloxacin to treat bacterial infections | |
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1983, introduced | |
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Used mainly for lower respiratory tract, skin, eye and urinary tract infections. | |
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Cats; Dogs |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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C₁₇H₁₈FN₃O₃ | |
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C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O | |
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No data | |
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MYSWGUAQZAJSOK-UHFFFAOYSA-N | |
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InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) | |
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Yes |
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Common Name | Relationship | Link |
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ciprofloxacin | - |
General status |
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Medicinal drug, Antibacterial, Antibiotic | |
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Fluoroquinolone | |
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Synthetic | |
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Enters bacterial cells and inhibits the enzyme DNA-gyrase that is involved in replicating and repairing DNA | |
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[DNA topoisomerase 4 subunit A, Antagonist], [DNA gyrase subunit A, Antagonist], [DNA topoisomerase 2-alpha, Antagonist] | |
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85721-33-1 | |
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Antiinfectants for systemic use: Antibacterials for systemic use; Sensory organs: Opthalmologicals, Otologicals, Opthalmological & otological preparations | |
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QJ01MA02; QS01AX13,QS02AA15, QS03AA07 | |
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No | |
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331.35 | |
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1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid | |
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1-cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid | |
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White or pale yellow, slightly hygroscopic, crystalline powder | |
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Formulations |
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Ciproxin | Bayer plc | Not licensed | Not licensed | ||||||
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3000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
High | ||||||||
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318 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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1.07 X 1001 | Calculated | - | |||||||
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1.03 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Low | ||||||||
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6.27 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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2.19 X 10-07 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low volatility | ||||||||
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Degradation |
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Literature quotes substance mostly disappeared after 65 days | ||||||||||
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2.05 | R4 R = Peer reviewed scientific publications Sewage sludge4 = Verified data |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | R4 R = Peer reviewed scientific publications 4 = Verified data |
Non-mobile | |||||||
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6100 | ||||||||||
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Data for loamy sand; Other studies Koc range 35342-134465 mL g⁻¹ | ||||||||||
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 2000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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> 100 | E3 E = Manufacturers safety data sheets Danio rerio3 = Unverified data of known source |
Low | ||||||||
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> 60 | E3 E = Manufacturers safety data sheets Daphnia magna3 = Unverified data of known source |
Moderate | ||||||||
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> 4 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Ceriodaphnia dubia LC₅₀4 = Verified data |
Moderate | ||||||||
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2.97 | E3 E = Manufacturers safety data sheets Pseudokirchneriella subcapitata3 = Unverified data of known source |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 2000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Low | ||||||||
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Subcutaneous LD₅₀ > 1000 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intraperitoneal LD₅₀ = 122 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Excretion is rapid <1day, ~50% is excreted in urine as unchanged drug and about 15% as metabolites. Also identified in breast milk. | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Possible liver and kidney toxicant May cause gastrointestinal and cardiovascular problems May cause headache, dizziness, confusion, insomnia and restlessness May cause hypersensitivity and skin reactions |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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ciprofloxacin | ||
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ciprofloxacine | ||
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ciprofloxacino | ||
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Record last updated: | 18/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |