Marbofloxacin |
Last updated: 18/05/2024 |
(Not known by any other names) |
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A broad-spectrum fluoroquinolone antibiotic veterinary drug | |
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Current | |
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1991, discovered | |
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Used to treat infections of the skin, respiratory system, urinary tract and mammary glands, as well as those of the urinary tract | |
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Dogs; Cats; Cattle |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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- | |
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C₁₇H₁₉FN₄O₄ | |
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CN1CCN(CC1)C2=C(C=C3C4=C2OCN(N4C=C(C3=O)C(=O)O)C)F | |
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No data | |
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BPFYOAJNDMUVBL-UHFFFAOYSA-N | |
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InChI=1S/C17H19FN4O4/c1-19-3-5-21(6-4-19)14-12(18)7-10-13-16(14)26-9-20(2)22(13)8-11(15(10)23)17(24)25/h7-8H,3-6,9H2,1-2H3,(H,24,25) | |
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Yes |
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Common Name | Relationship | Link |
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marbofloxacin | - |
General status |
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Antibiotic, Antibacterial | |
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Fluoroquinolone | |
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98% | |
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Synthetic | |
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Broad spectrum, acts by inhibiting bacterial DNA replication | |
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[DNA gyrase subunit A, Antagonist] | |
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115550-35-1 | |
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Antiinfectants for systemic use: Antibacterials for systemic use | |
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QJ01MA93 | |
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No | |
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Allowed substance (Table 1: Bovine, Porcine) | |
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362.36 | |
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9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyridol(3,2,1-ij)(4,2,1)benzoxadiazin-6 carboxylic acid | |
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9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(3,2,1-ij)(4,1,2)benzoxadiazine-6-carboxylic acid | |
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Pale yellow, crystalline powder | |
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Formulations |
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Aurizon Ear Drops suspension | Vetoquinol UK Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Boflox Flavour Tablets | Livisto International S.L. | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Gefriderm Cutaneous Spray Solution | Alpha-vet Allatgyogyaszati Kft | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Marbocyl Tablets | Vetoquinol UK Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Available in a range of different formulations including solutions for injection, ear drops, tablets and cutaneous sprays |
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268 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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1.46 X 10-01 | Calculated | - | |||||||
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-0.835 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
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Terrestrial ecotoxicology |
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> 1781 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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Aquatic ecotoxicology |
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62.3 | E3 E = Manufacturers safety data sheets Daphnia magna3 = Unverified data of known source |
Low | ||||||||
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> 5.0 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Ceriodaphnia dubia LC₅₀4 = Verified data |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 1781 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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Excreted mostly unchanged in the urine, only small proportion is metabolised and excreted in the bile. | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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Possible liver and kidney toxicant May cause vomiting, reddening of the skin, weight loss and dehydration May cause photosensitisation |
Handling issues |
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Dust may be hazardous | |||
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Not listed (Not listed) | |||
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marbofloxacin | ||
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marbofloxacine | ||
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marbofloxacino | ||
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Record last updated: | 18/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |