Cloprostenol sodium |
Last updated: 19/01/2024 |
(Not known by any other names) |
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Cloprostenol sodium is a (racemic) analogue of prostaglandin F2α (PGF2α) and used for its potemnt luteolytic properties | |
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Current | |
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Used to terminate pregnancy, induce parturition, and control the breeding pattern of a herd/flock or individual animals for effective stud management. | |
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Cattle; Pigs; Sheep; Horses |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Racemate | |
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C₂₂H₂₈ClO₆Na | |
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C1C(C(C(C1O)C=CC(COC2=CC(=CC=C2)Cl)O)CC=CCCCC(=O)[O-])O.[Na+] | |
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IFEJLMHZNQJGQU-UDEWSXLWSA-M | |
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InChI=1S/C22H29ClO6.Na/c23-15-6-5-7-17(12-15)29-14-16(24)10-11-19-18(20(25)13-21(19)26)8-3-1-2-4-9-22(27)28;/h1,3,5-7,10-12,16,18-21,24-26H,2,4,8-9,13-14H2,(H,27,28);/q;+1/p-1 | |
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Yes |
General status |
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Fertility drug, Medicinal drug | |
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Prostaglandin | |
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~98% | |
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15S-cloprostenol ~1%; 5,6-trans-cloprostenol ~2% | |
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Synthetic | |
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Induces in a sharp fall in progesterone levels | |
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[Prostaglandin F2-alpha receptor, Agonist] | |
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55028-72-3 | |
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255-028-8 | |
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44134632 | |
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Genito urinary system & sex hormones: Prostaglandins | |
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QG02AD90 | |
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No | |
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Allowed substance (Table 1: Bovine, Porcine, Caprine, Equidae) | |
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446.92 | |
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7-[2-[4-(3-chlorophenoxy)-3-hydroxybut-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoate, sodium salt | |
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(+)-16-m-chlorophenoxy tetranor Prostaglandin F2a (sodium salt), superphan, D-cloprostenol | |
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White amorphous, hygroscopic powder | |
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Formulations |
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10 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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50000 | Q3 Q = Miscellaneous data from online sources Ethanol3 = Unverified data of known source |
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60000 | Q3 Q = Miscellaneous data from online sources DMSO3 = Unverified data of known source |
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130000 | Q3 Q = Miscellaneous data from online sources Dimethylformamide3 = Unverified data of known source |
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69 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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Max: 220nm, 275nm, 282nm | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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25 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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General |
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High (class III) | - | - | ||||||||
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25 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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May be absorbed through the skin | ||||||||||
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Eliminated in approximately equal amounts via the kidney and in bile. Excretion in urine is partly as unchanged parent and partly as metabolites. | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Possible sensitiser May cause vomiting and nausea |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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cloprostenol sodium | ||
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Record last updated: | 19/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |