Cloprostenol |
Last updated: 19/01/2024 |
(Not known by any other names) |
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Cloprostenol is an analogue of prostaglandin F2α (PGF2α) and used for its potemnt luteolytic properties | |
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Current | |
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Used to terminate pregnancy, induce parturition, and control the breeding pattern of a herd/flock or individual animals for effective stud management. | |
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Cattle; Pigs; Sheep; Horses |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Racemate | |
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C₂₂H₂₉ClO₆ | |
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C1C(C(C(C1O)C=CC(COC2=CC(=CC=C2)Cl)O)CC=CCCCC(=O)O)O | |
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C1[C@@H]([C@@H]([C@H]([C@@H]1O)/C=C/[C@H](COC2=CC(=CC=C2)Cl)O)C/C=C\CCCC(=O)O)O | |
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VJGGHXVGBSZVMZ-QIZQQNKQSA-N | |
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InChI=1S/C22H29ClO6/c23-15-6-5-7-17(12-15)29-14-16(24)10-11-19-18(20(25)13-21(19)26)8-3-1-2-4-9-22(27)28/h1,3,5-7,10-12,16,18-21,24-26H,2,4,8-9,13-14H2,(H,27,28)/b3-1-,11-10+/t16-,18-,19-,20+,21-/m1/s1 | |
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Yes |
General status |
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Fertility drug, Medicinal drug | |
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Prostaglandin | |
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~98% | |
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Synthetic | |
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Induces in a sharp fall in progesterone levels | |
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[Prostaglandin F2-alpha receptor, Agonist] | |
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54276-21-0 | |
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40665-92-7 | |
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255-028-8 | |
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5311053 | |
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Genito urinary system & sex hormones: Prostaglandins | |
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QG02AD90 | |
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No | |
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Allowed substance (Table 1: Bovine, Porcine, Caprine, Equidae) | |
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424.9 | |
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(Z)-7-[(1R,2R,3R,5S)-2-[(E,3R)-4-(3-chlorophenoxy)-3-hydroxybut-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoic acid | |
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White amorphous, hygroscopic powder | |
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Formulations |
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Bioestrovet Solution for Injection | Vetoquinol UK Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Dalmazin 75 ug/ml solution for injection for cows and sows | FATRO S.p.A. | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Juramate 250 µg/ml Solution for Injection | Zoetis UK Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Planate 0.0875 mg/ml Solution for injection | MSD Animal Health UK Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Formulated as a solution for injection |
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10 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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50000 | Q3 Q = Miscellaneous data from online sources Ethanol3 = Unverified data of known source |
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60000 | Q3 Q = Miscellaneous data from online sources DMSO3 = Unverified data of known source |
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130000 | Q3 Q = Miscellaneous data from online sources Dimethylformamide3 = Unverified data of known source |
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69 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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Max: 220nm, 275nm, 282nm | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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25 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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General |
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High (class III) | - | - | ||||||||
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25 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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May be absorbed through the skin | ||||||||||
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Eliminated in approximately equal amounts via the kidney and in bile. Excretion in urine is partly as unchanged parent and partly as metabolites. | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Possible sensitiser May cause vomiting and nausea |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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cloprostenol | ||
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Record last updated: | 19/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |