Sulphadimethoxine |
Last updated: 25/01/2024 |
(Also known as: sulfadimethoxine; sulfadimetoxin; SDM) |
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Broad spectrum sulphonamide drug with veterinary applications which is usually formulated as the sodium salt. | |
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Current | |
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Used to treat a variety of infections including those of the respiratory tract, urinary tract and soft tissue infections. It is also used for the treatment of coccidiosis. | |
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Dogs; Horses; Cattle; Birds; Cats; Dogs; Poultry; Pigs; Sheep |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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C₁₂H₁₄N₄O₄S | |
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COC1=NC(=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N)OC | |
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ZZORFUFYDOWNEF-UHFFFAOYSA-N | |
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InChI=1S/C12H14N4O4S/c1-19-11-7-10(14-12(15-11)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16) | |
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Yes |
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Common Name | Relationship | Link |
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sulphadimethoxine | - |
General status |
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Antibiotic, Antibacterial, Antiprotozoal, Coccidiostat, Antiparasitic, Medicinal drug | |
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Sulphonamide | |
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Synthetic | |
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Inhibits the conversion of para-aminobenzoic acid to dihydrofolic acid and so inhibits bacterial synthesis | |
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[Cytochrome P450 2C9, Inhibitor] | |
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122-11-2 | |
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204-523-7 | |
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Antiinfectants for systemic use: Antibacterials for systemic use, Antiprotozoals | |
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QJ01EQ09; QP51AG02 | |
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No | |
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Allowed substance (Table 1: All food producing species) | |
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310.33 | |
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4-amino-N-(2,6-dimethoxypyrimidin-4-yl)benzenesulfonamide | |
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4-amino-N-(2,6-dimethoxy-4-pyrimidinyl)benzolsulfonamid | |
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White powder | |
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Formulations |
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Usually supplied as the sodium salt liquid suspension in sachets and given by mouth but also available in tablet form |
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343 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Moderate | ||||||||
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200 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Decomposes before boiling | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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4.27 X 1000 | Calculated | - | |||||||
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0.63 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Low | ||||||||
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5.54 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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2.11 X 10-04 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Low volatility | ||||||||
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | R4 R = Peer reviewed scientific publications 4 = Verified data |
Slightly mobile | |||||||
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1672 | ||||||||||
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Koc 2517 mL g⁻¹ soil with 81.5% sand, 4856 mL g⁻¹ soil with 52% sand | ||||||||||
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 1000 | E3 E = Manufacturers safety data sheets Rabbit3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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> 400 | Q3 Q = Miscellaneous data from online sources Oncorhynchus mykiss3 = Unverified data of known source |
Low | ||||||||
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> 1000 | R4 R = Peer reviewed scientific publications Danio rerio4 = Verified data |
Low | ||||||||
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189 | R4 R = Peer reviewed scientific publications Daphnia magna4 = Verified data |
Low | ||||||||
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2.3 | R4 R = Peer reviewed scientific publications Selenastrum capricornutum4 = Verified data |
Moderate | ||||||||
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> 0.53 | R4 R = Peer reviewed scientific publications Selenastrum capricornutum4 = Verified data |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 1000 | E3 E = Manufacturers safety data sheets Rabbit3 = Unverified data of known source |
Moderate | ||||||||
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Intravenous LD₅₀ = 1000 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rabbit3 = Unverified data of known source |
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Subcutaneous LD₅₀ = 791 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Metabolised and excreted mainly in the urine | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May cause vomiting and diarrhoea Possible kidney and liver toxicant |
Handling issues |
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Hygroscopic | |||
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Not listed (Not listed) | |||
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sulphadimethoxine | ||
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sulfadimetossina | ||
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sulfametoxina | ||
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Record last updated: | 25/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |