Emodepside |
Last updated: 18/05/2024 |
(Also known as: BAY 44-4400; BAY 44-8; PF 1022-221) |
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A semi-synthetic, anthelmintic depsipeptide veterinary drug | |
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Current | |
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1990, research started | |
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Effective against a number of gastrointestinal nematodes including ascarids and hookworms | |
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Cats; Dogs |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₆₀H₉₀N₆O₁₄ | |
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CC1C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)O1)CC(C)C)C)CC2=CC=C(C=C2)N3CCOCC3)CC(C)C)C)C)CC(C)C)C)CC4=CC=C(C=C4)N5CCOCC5)CC(C)C)C | |
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C[C@@H]1C(=O)N([C@H](C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N([C@H](C(=O)O1)CC(C)C)C)CC2=CC=C(C=C2)N3CCOCC3)CC(C)C)C)C)CC(C)C)C)CC4=CC=C(C=C4)N5CCOCC5)CC(C)C)C | |
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ZMQMTKVVAMWKNY-YSXLEBCMSA-N | |
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InChI=1S/C60H90N6O14/c1-37(2)31-47-57(71)77-41(9)53(67)61(11)50(34-40(7)8)60(74)80-52(36-44-17-21-46(22-18-44)66-25-29-76-30-26-66)56(70)64(14)48(32-38(3)4)58(72)78-42(10)54(68)62(12)49(33-39(5)6)59(73)79-51(55(69)63(47)13)35-43-15-19-45(20-16-43)65-23-27-75-28-24-65/h15-22,37-42,47-52H,23-36H2,1-14H3/t41-,42-,47+,48+,49+,50+,51-,52-/m1/s1 | |
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Yes |
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Common Name | Relationship | Link |
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emodepside hydrate | - |
General status |
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Antiparasitic, Anthelmintic, Nematicide | |
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Cyclic octadepsipeptides | |
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>950g kg⁻¹ | |
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Semi-synthetic | |
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Acts by stimulation of the presynaptic latrophilin receptor causing paralysis and death of the parasite | |
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[Latrophilin receptor, Binder] | |
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155030-63-0 | |
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Antiparasitic products, insecticides & repellents: Anthelmintics | |
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QP52AA51 | |
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No | |
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1119.39 | |
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cyclo[(R)-2-hydroxypropanoyl-(N-méthyl-L-leucyl)-[(R)-3-[4-(morpholin-4-yl)phényl]-2-hydroxypropanoyl]-(N-méthyl-L-leucyl)-(R)-2-hydroxypropanoyl-(N-méthyl-L-leucyl)-[(R)-3-[4-(morpholin-4-yl)phényl]-2-hydroxypropanoyl]-(N-méthyl-L-leucyl)] | |
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White to pale yellow powder | |
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Formulations |
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Dronspot Spot-on Solution | Vetoquinol UK Ltd | GB National authorisation | For non-food animal use and may be supplied without a prescription by a suitable qualified person (NFA-VPS) | ||||||
Felpreva Spot-on Solution | Vetoquinol UK Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Profender Tablets | Vetoquinol UK Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Usually available as pour-on products or modified-release tablets for oral administration |
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5.2 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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7.94 X 1004 | Calculated | - | |||||||
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4.9 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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Faecal excretion predominates | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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No further information available |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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emodepside | ||
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Record last updated: | 18/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |