Fentanyl |
Last updated: 18/05/2024 |
(Not known by any other names) |
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A potent class-II opiate narcotic veterinary medication. it is often formulated using the citrate. | |
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Current | |
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1960, first synthesised | |
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Mainly used as a sedative or tranquilizer for various veterinary surgical procedures and for severe pain management | |
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Sheep; Goats; Dogs; Cats; Bears; Pigs; Rats; Mice; Rabbits |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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C₂₂H₂₈N₂O | |
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CCC(=O)N(C1CCN(CC1)CCC2=CC=CC=C2)C3=CC=CC=C3 | |
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PJMPHNIQZUBGLI-UHFFFAOYSA-N | |
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InChI=1S/C22H28N2O/c1-2-22(25)24(20-11-7-4-8-12-20)21-14-17-23(18-15-21)16-13-19-9-5-3-6-10-19/h3-12,21H,2,13-18H2,1H3 | |
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Yes |
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Common Name | Relationship | Link |
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fentanyl | - | |
fentanyl citrate | Variant |
General status |
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Analgesic, Anesthetic, Medicinal drug | |
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Synthetic opioid | |
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Synthetic | |
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A mu-opioid agonist | |
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[Mu-type opioid receptor, Agonist], [Delta-type opioid receptor, agonist], [Kappa-type opioid receptor, Agonist] | |
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437-38-7 | |
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207-113-6 | |
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Nervous system: Anesthetics | |
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QN01AH51 | |
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UK: Class A, Schedule 2; EU: UN61/72, Class I | |
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336.47 | |
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N-(1-(2-phenylethyl)-4-piperidinyl)-N-phenylpropanamide | |
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1-phenethyl-4-(phenylproprionylamino)piperidine | |
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USA Superlist DEA Schedule II | |
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White crystalline powder | |
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Formulations |
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Fentadon Solution for Injection | Eurovet Animal Health B.V. | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
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Usually formulated, sometimes as the citrate, as solutions for injection |
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200 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Moderate | ||||||||
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87 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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1.12 X 1004 | Calculated | - | |||||||
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4.05 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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7.3 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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pKa(2) = 8.41 | |||||||||||
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
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norfentanyl Note: Pharmacologically inactive |
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4-N-anilinopiperidine | - | Hydrolysis | - | ||||
propionic acid | - | Hydrolysis | - |
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Terrestrial ecotoxicology |
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3.1 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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3.1 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
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Subcutaneous LD₅₀ = 1.5 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intravenous LD₅₀ = 2.91 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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May be absorbed through dermal contact | ||||||||||
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Considerable metabolism, up to 75% excreted as metabolites in the urine, less lost via the faeces, <10% unchanged | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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May cause diarrhoea, nausea, constipation, dry mouth, somnolence and confusion May cause respiratory depression |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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fentanyl | ||
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fentanila | ||
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Record last updated: | 18/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |