Selamectin |
Last updated: 06/03/2024 |
(Also known as: selamectine) |
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An avermectin, antiparasitic and anthelmintic veterinary drug | |
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Current | |
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2000, first introduced USA | |
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Used for preventing heartworms and controlling fleas and is also used for treating ear mites and other parasites | |
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Dogs; Cats; Ferrets; Rodents |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Salamectin is a chiral molecule | |
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C₄₃H₆₃NO₁₁ | |
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CC1CCC2(CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5=NO)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)O)OC)C)OC1C7CCCCC7 | |
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C[C@H]1CC[C@]2(C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]\5[C@@]4([C@@H](C=C(/C5=N/O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O)OC)\C)O[C@@H]1C7CCCCC7 | |
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AFJYYKSVHJGXSN-XHKIUTQPSA-N | |
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InChI=1S/C43H63NO11/c1-24-11-10-14-30-23-50-40-36(44-48)27(4)19-33(43(30,40)47)41(46)52-32-20-31(16-15-25(2)38(24)53-35-21-34(49-6)37(45)28(5)51-35)54-42(22-32)18-17-26(3)39(55-42)29-12-8-7-9-13-29/h10-11,14-15,19,24,26,28-29,31-35,37-40,45,47-48H,7-9,12-13,16-18,20-23H2,1-6H3/b11-10+,25-15+,30-14+,44-36-/t24-,26-,28-,31+,32-,33-,34-,35-,37-,38-,39-,40+,42+,43+/m0/s1 | |
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Yes |
General status |
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Antiparasitic, Insecticide, Antihelminthic, Acaricide | |
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Avermectin | |
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Synthetic | |
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Disables parasites by replacing glutamate in their muscle synapses. Glutamate-gated chloride channel (GluCl) allosteric modulator. | |
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[Glutamate receptor 1, Antagonist] | |
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165108-07-6 | |
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220119-17-5 | |
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Antiparasitic products, insecticides & repellents: Endectocides | |
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QP54AA05 | |
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No | |
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- | |
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769.96 | |
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- | |
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(10E,14E,16E,21Z)-(1R,4S,5'S,6R,6'S,8R,12S,13S,20R,21R,24S)-6'-cyclohexyl-24-hydroxy-21-hydroxyimino-5',11,13,22-tetramethyl-2-oxo-(3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene)-6-spiro-2'-(tetrahydropyran)-12-yl 2,6-dideoxy-3-O-methyl-a-L-arabino-hexopyranoside | |
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(5Z,25S)-25-cyclohexyl-4'-O-de(2,6-dideoxy-3-O-methyl-a-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)avermectin A1a | |
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Formulations |
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Chanhold Spot-on Solution | Chanelle Pharmaceuticals Manufacturing Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Evicto Spot-on Solution | Virbac | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Selapro Spot-on Solution | Norbrook Laboratories Itd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Stronghold spot-on Solution | Zoetis UK Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Usually formulated as a solution for 'spot-on' trearment |
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0.435 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Low | ||||||||
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1.41 X 1003 | Calculated | - | |||||||
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3.15 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
High | ||||||||
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2.0 X 10-11 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Low volatility | ||||||||
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Non-mobile | |||||||
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213546 | ||||||||||
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EU Veterinary document Koc range 24459 to 402633 mL g⁻¹ | ||||||||||
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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abamectin (Ref: MK 936) | - | - | - |
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Terrestrial ecotoxicology |
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> 1600 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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266 | E3 E = Manufacturers safety data sheets Oncorhynchus mykiss3 = Unverified data of known source |
Low | ||||||||
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0.000026 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Daphnia magna5 = Verified data used for regulatory purposes |
High | ||||||||
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0.028 | E3 E = Manufacturers safety data sheets Mysidopsis bahia3 = Unverified data of known source |
High | ||||||||
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28 | E3 E = Manufacturers safety data sheets Red algae3 = Unverified data of known source |
Low | ||||||||
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> 766 | E3 E = Manufacturers safety data sheets Selenastrum capricornutum3 = Unverified data of known source |
Low | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 1600 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Moderate | ||||||||
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In dogs: majority excreted in shed hair and faeces, remainder identified in urine and house/bedding rinse water | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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No further information available |
Handling issues |
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IMDG Transport Hazard Class 9 | |||
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Not listed (Not listed) | |||
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UN3077 | |||
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Packaging Group II (moderate danger) | |||
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selamectin | ||
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selamectine | ||
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Selamectin | ||
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selamectin | ||
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selamectin | ||
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selamectina | ||
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selamectin | ||
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selamektyna | ||
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selamectin | ||
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selamectin | ||
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- | ||
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- |
Record last updated: | 06/03/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |