Carbimazole |
Last updated: 18/05/2024 |
(Also known as: athyromazole; carbethoxymethimazole; carbinazole ) |
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A prodrug of methimazole used as anti-thyroid-medication | |
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Current | |
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1953, first licensed for clinical use | |
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Used to treat hyperthyroidism | |
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Cats; Dogs |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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- | |
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C₇H₁₀N₂O₂S | |
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CCOC(=O)N1C=CN(C1=S)C | |
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No data | |
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CFOYWRHIYXMDOT-UHFFFAOYSA-N | |
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InChI=1S/C7H10N2O2S/c1-3-11-7(10)9-5-4-8(2)6(9)12/h4-5H,3H2,1-2H3 | |
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Yes |
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Common Name | Relationship | Link |
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carbimazole | - |
General status |
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Anti-thyroid drug, Prodrug, Thionamide | |
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Thioamide | |
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97% | |
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Synthetic | |
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Thyroid peroxidase inhibitor | |
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[Thyroid peroxidase, Antagonist] | |
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22232-54-8 | |
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244-854-4 | |
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Systemic hormone preparations excluding sex hormones & insulins: Thyroid therapy | |
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QH03BB01 | |
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No | |
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186.23 | |
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ethyl 3-methyl-2-sulfanylidene-imidazole-1-carboxylate | |
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3-methyl-2-thioxo-4-imidazoline-1-carboxylic acid ethyl ester | |
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White to yellowish-white crystalline powder |
Formulations |
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Vidalta 10mg tablets for cats | MSD Animal Health UK Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Felinta Tablets | Milstein C.V. | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Often formulated as prolonged-release tablets for oral administration |
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123 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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130 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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3.39 X 1000 | Calculated | - | |||||||
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0.53 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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1.04 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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In water: 291nm In acid: 227nm & 291nm |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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thiamazole Note: Pharmacologically active |
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Terrestrial ecotoxicology |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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May be absorbed through the skin | ||||||||||
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Excreted in the urine as thiamazole or its metabolites | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May cause skin rashes May cause bone marrow suppression May cause hair loss |
Handling issues |
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Emits toxic fumes under fire conditions | |||
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Not listed (Not listed) | |||
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carbimazole | ||
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carbimazol | ||
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carbimazol | ||
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Record last updated: | 18/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |