Ormetoprim |
Last updated: 10/01/2024 |
(Also known as: ormethoprim) |
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A long-lasting drug used in potentiated sulfonamide mixtures used as coccidiostats | |
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Numerous veterinary uses including the treatment of protozoal diseases such as leishmaniasis and toxoplasmosis | |
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Poultry; Fish; Sheep; Dogs |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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C₁₄H₁₈N₄O₂ | |
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CC1=CC(=C(C=C1CC2=CN=C(N=C2N)N)OC)OC | |
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No data | |
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KEEYRKYKLYARHO-UHFFFAOYSA-N | |
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InChI=1S/C14H18N4O2/c1-8-4-11(19-2)12(20-3)6-9(8)5-10-7-17-14(16)18-13(10)15/h4,6-7H,5H2,1-3H3,(H4,15,16,17,18) | |
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Yes |
General status |
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Antimicrobial, Antibiotic, Medicinal drug | |
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Diaminopyrimidine | |
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Synthetic | |
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Interferes with folic acid production by inhibition of dihydrofolate reductase | |
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[Dihydrofolate reductase, Inhibitor] | |
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6981-18-6 | |
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230-246-6 | |
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Antiinfectives for Systemic use: Combinations of sulfonamides and trimethoprim, incl. derivatives | |
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QJ01EW19 | |
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No | |
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274.32 | |
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5-(4,5-dimethoxy-2-methylbenzyl)-2,4-diaminopyrimidine | |
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2,4-diamino-5-(6-methylveratryl)pyrimidine | |
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Formulations |
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1540 | R4 R = Peer reviewed scientific publications 4 = Verified data |
High | ||||||||
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1.70 X 1001 | Calculated | - | |||||||
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1.23 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Low | ||||||||
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- | R2 R = Peer reviewed scientific publications 2 = Unverified data of unknown source |
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Weak base | |||||||||||
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3.03 X 10-03 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Low volatility | ||||||||
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | R4 R = Peer reviewed scientific publications 4 = Verified data |
Slightly mobile | |||||||
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3687 | ||||||||||
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Koc 2517 mL g⁻¹ soil with 81.5% sand, 4856 mL g⁻¹ soil with 52% sand | ||||||||||
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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665 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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400 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Salmo gairdneri3 = Unverified data of known source |
Low | ||||||||
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33 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna4 = Verified data |
Moderate | ||||||||
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90 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Selenastrum capricornutum3 = Unverified data of known source |
Low | ||||||||
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General |
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High (class III) | - | - | ||||||||
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665 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Moderate | ||||||||
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Health issues |
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No further information available |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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|
ormetoprim | ||
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ormetoprime | ||
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ormetoprima | ||
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Record last updated: | 10/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |