Ofloxacin |
Last updated: 19/05/2024 |
(Also known as: floxin; HOE 280) |
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A broad-spectrum antibiotic active against both gram-positive and gram-negative bacterial infections | |
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1982, first patented | |
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Used to treat external eye infections such as some types of conjunctivitis | |
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Dogs; Cats |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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C₁₈H₂₀FN₃O₄ | |
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CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O | |
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No data | |
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GSDSWSVVBLHKDQ-UHFFFAOYSA-N | |
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InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25) | |
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Yes |
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Common Name | Relationship | Link |
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ofloxacin | - |
General status |
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Antibiotic, Bactericide, Medicinal drug | |
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Fluoroquinolone | |
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Synthetic | |
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Inhibits DNA gyrase | |
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[DNA topoisomerase 4 subunit A, Antagonist], [DNA gyrase subunit A, Antagonist], [DNA topoisomerase 2-alpha, Antagonist] | |
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82419-36-1 | |
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Sensory organs: Ophthalmologicals, Otologicals | |
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QS01AX11; QS02AA16 | |
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No | |
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361.37 | |
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(RS)-7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid | |
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9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid | |
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Evidence of use in third world countries | |
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Solid | |
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Formulations |
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28300 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
High | ||||||||
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254 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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1.02 X 1001 | Calculated | - | |||||||
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1.01 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Low | ||||||||
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5.97 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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2.06 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low volatility. If applied directly to plants or soil, drift is a concern & mitigation is advisable | ||||||||
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Non-mobile | |||||||
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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3590 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Low | ||||||||
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Aquatic ecotoxicology |
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> 16 | R4 R = Peer reviewed scientific publications Danio rerio 10 day4 = Verified data |
Low | ||||||||
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26.7 | R4 R = Peer reviewed scientific publications Ceriodaphnia dubia4 = Verified data |
Moderate | ||||||||
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10 | R3 R = Peer reviewed scientific publications Ceriodaphnia dubia 7 day3 = Unverified data of known source |
Moderate | ||||||||
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> 1.05 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Ceriodaphnia dubia4 = Verified data |
Moderate | ||||||||
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0.532 | R4 R = Peer reviewed scientific publications Lemna gibba4 = Verified data |
Moderate | ||||||||
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4.74 | R4 R = Peer reviewed scientific publications Pseudokirchneriella subcapitata4 = Verified data |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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3590 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Low | ||||||||
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Subcutaneous LD₅₀ = 7070 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intravenous LD₅₀ = 273 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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65 - 80% of administered oral dose is excreted unchanged via the kidneys within 48 hours of dosing, <8% is excreted in the faeces. These is also a small amount of bilary excretion. | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May cause tendon deterioration May cause serious psychiatric side effects May cause sunlight sensitivity |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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ofloxacin | ||
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ofloxacine | ||
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ofloxacino | ||
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Record last updated: | 19/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |