Lomefloxacin hydrochloride |
Last updated: 14/01/2024 |
(Also known as: lomefloxacin HCl) |
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An antibiotic drug active against both Gam-positive and gram-negative bacteria | |
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Used to treat bacterial infections particularly those of the respiratory and urinary tracts in poultry | |
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Poultry |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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C₁₇H₂₀F₂N₃O₃Cl | |
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CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O.Cl | |
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No data | |
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KXEBLAPZMOQCKO-UHFFFAOYSA-N | |
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InChI=1S/C17H19F2N3O3/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25) | |
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Yes |
General status |
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Antibiotic, Antibacterial, Medicinal drug | |
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Fluoroquinolone | |
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Synthetic | |
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Bactericidal action results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA | |
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[DNA topoisomerase 4 subunit A, Antagonist], [DNA gyrase subunit A, Antagonist], [DNA topoisomerase 2-alpha, Antagonist] | |
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98079-52-8 | |
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Antiinfectants for systemic use: Antibacterials for systemic use; Sensory organs: Ophthalmologicals | |
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QJ01MA07; QS01AX17 | |
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No | |
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387.8 | |
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(RS)-1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic acid hydrochloride | |
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1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid hydrochloride | |
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White to pale yellow coloured powder | |
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Formulations |
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27200 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
High | ||||||||
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240 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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9.77 X 1000 | Calculated | - | |||||||
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0.99 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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5.9 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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6.28 X 10-08 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low volatility | ||||||||
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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- | lomefloxacin glucuronide | - | ~9% of administered dose |
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Terrestrial ecotoxicology |
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> 3800 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Low | ||||||||
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Aquatic ecotoxicology |
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170 | R4 R = Peer reviewed scientific publications Oncorhynchus mykiss as acid4 = Verified data |
Low | ||||||||
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130 | R4 R = Peer reviewed scientific publications Daphnia magna as acid4 = Verified data |
Low | ||||||||
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58.0 | R4 R = Peer reviewed scientific publications Scenedesmus vacuolatus as acid4 = Verified data |
Low | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 3800 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
Low | ||||||||
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Subcutaneous LD₅₀ = 995 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
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Intravenous LD₅₀ = 328 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Excreted mainly via the urine within 72 hours of administration, around 65% of the dose is as the unchanged parent | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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Liver toxicant May cause nausea, vomiting or diarrhoea May cause sun sensitivity May cause tendon deterioration |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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lomefloxacin hydrochloride | ||
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chlorhydrate de lomefloxacine | ||
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hidrocloruro de lomefloxacino | ||
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Record last updated: | 14/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |