Spiramycin |
Last updated: 12/01/2024 |
(Also known as: rovamycin; foromacidin; sequamycin; selectomycin; rovomycin; provamycin) |
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An antibiotic used for the treatment and control of a number of bacterial and mycoplasmal infections | |
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Current | |
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2000, Europe | |
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Used for the treatment of various infections, including gingivitis, stomatitis, glossitis, periodontitis and dental fistular). It has also been used for mastitis, arthritis, foot rot and also as a growth promotor | |
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Poultry; Sheep; Cattle; Pigs; Cats; Dogs |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₄₃H₇₄N₂O₁₄ | |
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CC1CC=CC=CC(C(CC(C(C(C(CC(=O)O1)O)OC)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)O)(C)O)N(C)C)O)CC=O)C)OC4CCC(C(O4)C)N(C)C | |
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C[C@@H]1C/C=C/C=C/[C@@H]([C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)O)OC)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)O)(C)O)N(C)C)O)CC=O)C)OC4CCC(C(O4)C)N(C)C | |
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ACTOXUHEUCPTEW-JMRHEKERSA-N | |
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InChI=1S/C43H74N2O14/c1-24-21-29(19-20-46)39(59-42-37(49)36(45(9)10)38(27(4)56-42)58-35-23-43(6,51)41(50)28(5)55-35)40(52-11)31(47)22-33(48)53-25(2)15-13-12-14-16-32(24)57-34-18-17-30(44(7)8)26(3)54-34/h12-14,16,20,24-32,34-42,47,49-51H,15,17-19,21-23H2,1-11H3/b13-12+,16-14+/t24-,25-,26-,27-,28+,29+,30+,31-,32+,34+,35+,36-,37-,38-,39+,40+,41+,42+,43-/m1/s1 | |
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Yes |
General status |
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Antibiotic, Antibacterial, Medicinal drug, Growth promotor, Feed additive | |
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Macrolide | |
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Natural | |
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Inhibits protein synthesis | |
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[50S rRNA, Antagonist] | |
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8025-81-8 | |
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232-429-6 | |
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5289394 | |
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Antiinfectives for systemic use: Antibacterials for intramammary use, Antibacterials for systemic use | |
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QJ51FA02; QJ01RA04 | |
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No | |
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Allowed substance (Table 1 - Bovine, Chicken, Porcine) | |
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843.05 | |
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2-[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-[(2S,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-10-[(2R,5S,6R)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-4-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde | |
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2-[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-{[(2S,3R,4R,5S,6R)-5-{[(2S,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy}-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-10-{[(2R,5S,6R)-5-(dimethylamino)-6-methyloxan-2-yl]oxy}-4-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde | |
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Banned in EU as growth promotor; Not approved as a feed additive in EU | |
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White to pale yellow coloured solid | |
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Formulations |
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Spizobactin Chewable Tablets | Le Vet Beheer B.V. | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Stomorgyl Film-coated tablets | Boehringer Ingelheim Animal Health UK Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Usually formulated in combination with other medical substances as chewable or film-coated tablets |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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neospiramycin Note: Pharmacologically active |
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Terrestrial ecotoxicology |
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> 4850 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
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Aquatic ecotoxicology |
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2.3 | R4 R = Peer reviewed scientific publications Selenastrum capricornutum4 = Verified data |
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General |
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High (class III) | - | - | ||||||||
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> 4850 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
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Intravenous LD₅₀ = 170 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intraperitoneal LD₅₀ = 575 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Literature suggests biliary and subsequent faecal excretion | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
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Health issues |
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May impair hearing May cause gastrointestinal problems |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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spiramycin | ||
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spiramycine | ||
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espiramicina | ||
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Record last updated: | 12/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |