Oleandomycin |
Last updated: 10/01/2024 |
(Also known as: amimycin ; matromycin; landomycin; PA-105) |
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Veterinary macrolide antibiotic drug produced by Streptomyces antibioticus | |
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1954, first described | |
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Used in some countries to treat and prevent diseases and promote growth in food-producing animals | |
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Pigs; Poultry; Cattle |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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Isomeric | |
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C₃₅H₆₁NO₁₂ | |
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CC1CC(C(C(O1)OC2C(CC3(CO3)C(=O)C(C(C(C(OC(=O)C(C(C2C)OC4CC(C(C(O4)C)O)OC)C)C)C)O)C)C)O)N(C)C | |
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C[C@H]1C[C@]2(CO2)C(=O)[C@@H]([C@H]([C@H]([C@H](OC(=O)[C@@H]([C@H]([C@@H]([C@H]1OC3C(C(CC(O3)C)N(C)C)O)C)OC4CC(C(C(O4)C)O)OC)C)C)C)O)C | |
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RZPAKFUAFGMUPI-UQXMPEMXSA-N | |
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InChI=1S/C35H61NO12/c1-16-14-35(15-43-35)32(40)19(4)27(37)18(3)22(7)46-33(41)21(6)31(47-26-13-25(42-11)28(38)23(8)45-26)20(5)30(16)48-34-29(39)24(36(9)10)12-17(2)44-34/h16-31,34,37-39H,12-15H2,1-11H3/t16-,17+,18-,19+,20+,21+,22+,23-,24-,25-,26-,27-,28-,29+,30-,31-,34-,35-/m0/s1 | |
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Yes |
General status |
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Antibiotic, Antibacterial, Antimicrobial, Medicinal drug, Feed additive, growth Promotor | |
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Macrolide | |
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Natural | |
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Interferes with protein synthesis | |
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[50s subunit of bacterial ribosomes, Binder] | |
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3922-90-5 | |
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223-495-7 | |
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5284598 | |
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Antiinfectants for systemic use: Antibacterials for system use | |
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QJ01FA05 | |
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No | |
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687.86 | |
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(3S,5S,6S,7R,8S,9R,12R,13R,14S,15R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-hydroxy-8-[(2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-5,7,9,12,13,15-hexamethyl-1,11-dioxaspiro[2.13]hexadecane-10,16-dione | |
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Evidence of use in third world countries | |
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White amorphous powder | |
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Formulations |
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15.5 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) at 25 °C3 = Unverified data of known source |
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4.90 X 1001 | Calculated | - | |||||||
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1.69 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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8.5 | R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
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4.53 X 10-20 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low volatility | ||||||||
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Methanol: 286-289nm | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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23 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Non-persistent | |||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Low risk | Q3 Q = Miscellaneous data from online sources Based on LogP < 33 = Unverified data of known source |
Low risk | |||||||||||||||||||||||||
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 6700 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 6700 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
Low | ||||||||
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Subcutaneous LD₅₀ > 10000 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intravenous LD₅₀ = 440 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Excreted mainly in the bile | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May cause hyposensitivity May cause gastrointestinal problems |
Handling issues |
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When heated to decomposition emits toxic vapors of NOx | |||
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Not listed (Not listed) | |||
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oleandomycin | ||
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oleandomycine | ||
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oleandomicina | ||
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Record last updated: | 10/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |