Oxyclozanide |
Last updated: 27/04/2024 |
(Not known by any other names) |
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A salicylanide anthelmintic veterinary drug often used as an oral drench or a feed additive in combination with levamisole or oxfendazole | |
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Current | |
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Mainly used in the treatment and control of the parasitic infection, Fascioliasis, in ruminants | |
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Cattle; Sheep; Goats; Buffaloes |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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- | |
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C₁₃H₆Cl₅NO₃ | |
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C1=C(C=C(C(=C1Cl)O)NC(=O)C2=C(C(=CC(=C2Cl)Cl)Cl)O)Cl | |
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No data | |
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JYWIYHUXVMAGLG-UHFFFAOYSA-N | |
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InChI=1S/C13H6Cl5NO3/c14-4-1-6(16)11(20)8(2-4)19-13(22)9-10(18)5(15)3-7(17)12(9)21/h1-3,20-21H,(H,19,22) | |
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Yes |
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Common Name | Relationship | Link |
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oxyclozanide | - | |
oxyclozanide | - |
General status |
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Antiparasitic, Anthelmintic, Medicinal drug | |
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Salicylanilide | |
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Synthetic | |
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Acts by uncoupling of oxidative phosphorylation in flukes | |
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[Oxidative phosphorylation, Uncoupler] | |
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2277-92-1 | |
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218-904-0 | |
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Antiparasitic products, insecticides & repellents: Anthelmintics | |
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QP52AE51 | |
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Allowed substance (Table 1: Ruminants) | |
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401.46 | |
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2,3,5-trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxybenzamide | |
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Formulations |
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Downland Fluke and Worm Oral Suspension | Norbrook Laboratories Ltd | UK National authorisation (IC) | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | ||||||
Levafas Diamond Oral Suspension | Norbrook Laboratories Ltd | UK National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
Oxyfluke Oral Suspension | Norbrook Laboratories Ltd | GB National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
Zanil Fluke Drench | MSD Animal Health UK Ltd | UK National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
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Usually formulated as an oral suspension |
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205 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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1.10 X 1006 | Calculated | - | |||||||
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6.04 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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3519 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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3519 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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Around 85% of the administered dose is eliminated within 24hrs in the faeces | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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Possible liver toxicant |
Handling issues |
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IMDG Transport Hazard Class 9 | |||
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Not listed (Not listed) | |||
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UN3077 | |||
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Packaging Group III (minor danger) | |||
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oxyclozanide | ||
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oxiclozanida | ||
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Record last updated: | 27/04/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |