Tildipirosin |
Last updated: 13/01/2024 |
(Not known by any other names) |
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A semi-synthetic nacrolide veterinary drug used to treat gram-positive and gram-negative bacterial infections | |
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Current | |
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2017, first registered | |
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Used for the prevention and treatment of bacterial respiratory disease | |
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Cattle; Pigs |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₄₁H₇₁N₃O₈ | |
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CCC1C(C=C(C=CC(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(C(C(O2)C)O)N(C)C)O)CCN3CCCCC3)C)C)CN4CCCCC4 | |
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CC[C@@H]1[C@H](/C=C(/C=C/C(=O)[C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)O)C)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O)N(C)C)O)CCN3CCCCC3)C)\C)CN4CCCCC4 | |
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HNDXPZPJZGTJLJ-ZQFISELQSA-N | |
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InChI=1S/C41H71N3O8/c1-8-35-32(26-44-20-13-10-14-21-44)23-27(2)15-16-33(45)28(3)24-31(17-22-43-18-11-9-12-19-43)40(29(4)34(46)25-36(47)51-35)52-41-39(49)37(42(6)7)38(48)30(5)50-41/h15-16,23,28-32,34-35,37-41,46,48-49H,8-14,17-22,24-26H2,1-7H3/b16-15+,27-23+/t28-,29+,30-,31+,32-,34-,35-,37+,38-,39-,40-,41+/m1/s1 | |
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Yes |
General status |
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Antibacterial, Antibiotic, Medicinal drug | |
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Nacrolide | |
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Semi-synthetic | |
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Inhibits bacterial protein synthesis | |
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[50S rRNA, Antagonist] | |
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328898-40-4 | |
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24860548 | |
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Antiinfectants for systemic use: Antibacterials for systemic use | |
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QJ01FA96 | |
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No | |
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Allowed substance (Table 1: Bovine, Caprine, Porcine) | |
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734.02 | |
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(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4S,5S,6R)-4-(dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-5,9,13-trimethyl-7-(2-piperidin-1-ylethyl)-15-(piperidin-1-ylmethyl)-1-oxacyclohexadeca-11,13-diene-2,10-dione | |
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20,23-di-piperidinyl-mycaminosyl-tylonolide | |
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Formulations |
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Zuprevo Solution for Injection | MSD Animal Health Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
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Usually formulated as a solution for subcutaneous or intramuscular injection |
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1.50 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 6.25 | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Mouse3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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> 6.25 | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Mouse3 = Unverified data of known source |
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Major route of excretion in rats and dogs was via faeces | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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Possible kidney, liver, thyroid and adrenal glad toxicant |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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tildipirosin | ||
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tildipirosine | ||
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tildipirosina | ||
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Record last updated: | 13/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |