Amlodipine |
Last updated: 26/01/2024 |
(Not known by any other names) |
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A veterinary and human drug used to slow the heart beat and relax blood vessel walls. Often used as the besilate. | |
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Current | |
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1986, first approved USA | |
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Typically used to treat secondary hypertension caused by hyperthyroidism, diabetes, kidney disease or cardiomyopathy. | |
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Cats; Dogs |
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Approved | |
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Approved |
Chemical structure |
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Amlodipine technical material is a 1 : 1 racemate mixture | |
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C₂₀H₂₅ClN₂O₅ | |
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CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN | |
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HTIQEAQVCYTUBX-UHFFFAOYSA-N | |
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InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3 | |
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Yes |
General status |
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Medicinal drug: Vasodilator agent | |
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Dihydropyridine | |
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Amlodipine slows the rate at which calcium moves into the heart and blood vessel walls. Calcium channel blocker. | |
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[Voltage-dependent L-type calcium channel subunit alpha-1C, Inhibitor], [Voltage-dependent calcium channel subunit alpha-2/delta-1, Inhibitor], [Voltage-dependent L-type calcium channel subunit beta-2 , Inhibitor], [Voltage-dependent L-type calcium channel subunit alpha-1D, Inhibitor] | |
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88150-42-9 | |
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425-820-1 | |
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2162 | |
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Lipid modifying agent: HMG CoA reductase inhibitors, other combinations | |
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QC10BX11 | |
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No | |
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408.88 | |
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3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate | |
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3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylater | |
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3-ethyl 5-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate | |
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White powdery solid | |
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Formulations |
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Usually formulated as tablets for oral administration |
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75.3 | V2 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) at 25 °C2 = Unverified data of unknown source |
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1.00 X 1003 | Calculated | - | |||||||
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3.0 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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8.79 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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37 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse as besylate variant3 = Unverified data of known source |
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General |
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37 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse as besylate variant3 = Unverified data of known source |
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Heptic metabolism. Renal excretion accounts for approx. 60% administered. The remainder is eliminated in bile and faeces. | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Health issues |
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May cause swelling of ankles or feet May cause difficult or laboured breathing Possible liver & heart toxicant |
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Will release toxic gases if heated to decomposition Slightly flammable. May combust at high temperatures |
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Health: H301, H318, H373 Environment: H400, H410 |
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Not listed (Not listed) | |||
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amlodipine | ||
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amlodipino | ||
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Record last updated: | 26/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |