Amlodipine 2-phthalimide |
Last updated: 26/01/2024 |
(Not known by any other names) |
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A veterinary and human drug used to slow the heart beat and relax blood vessel walls | |
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Current | |
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1986, first approved USA | |
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Typically used to treat secondary hypertension caused by hyperthyroidism, diabetes, kidney disease or cardiomyopathy. | |
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Cats; Dogs |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Amlodipine technical material is a 1 : 1 racemate mixture | |
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C₂₉H₂₉ClN₂O₇ | |
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CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OCC)COCCN3C(=O)C4=CC=CC=C4C3=O)C | |
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NTVITRUDLZBADK-UHFFFAOYSA-N | |
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InChI=1S/C29H29ClN2O7/c1-4-38-28(35)23-17(3)31-22(25(29(36)39-5-2)24(23)20-12-8-9-13-21(20)30)16-37-15-14-32-26(33)18-10-6-7-11-19(18)27(32)34/h6-13,24,31H,4-5,14-16H2,1-3H3 | |
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Yes |
General status |
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Medicinal drug: Vasodilator agent | |
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Dihydropyridine | |
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Amlodipine slows the rate at which calcium moves into the heart and blood vessel walls. Calcium channel blocker. | |
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[Voltage-dependent L-type calcium channel subunit alpha-1C, Inhibitor], [Voltage-dependent calcium channel subunit alpha-2/delta-1, Inhibitor], [Voltage-dependent L-type calcium channel subunit beta-2 , Inhibitor], [Voltage-dependent L-type calcium channel subunit alpha-1D, Inhibitor] | |
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140171-49-9 | |
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11157139 | |
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Lipid modifying agent: HMG CoA reductase inhibitors, other combinations | |
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QC10BX11 | |
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553.0 | |
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diethyl 4-(2-chlorophenyl)-2-[2-(1,3-dioxoisoindol-2-yl)ethoxymethyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate | |
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Usually formulated as tablets for oral administration |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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37 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse as besylate variant3 = Unverified data of known source |
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General |
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37 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse as besylate variant3 = Unverified data of known source |
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Heptic metabolism. Renal excretion accounts for approx. 60% administered. The remainder is eliminated in bile and faeces. | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Health issues |
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May cause swelling of ankles or feet May cause difficult or laboured breathing Possible liver & heart toxicant |
Handling issues |
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Will release toxic gases if heated to decomposition Slightly flammable. May combust at high temperatures |
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Health: H301, H318, H373 Environment: H400, H410 |
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Not listed (Not listed) | |||
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amlodipine 2-phthalimide | ||
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Record last updated: | 26/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |