Fluralaner |
Last updated: 24/07/2024 |
(Not known by any other names) |
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An isoxazoline veterinary medicine administered orally or as a spot-on systemic insecticide and acacide | |
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Current | |
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Used for the treatment of fleas, ticks and other parasites in animals | |
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Dogs; Cats; Poultry; Cattle |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Racemic mixture | |
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C₂₂H₁₇Cl₂F₆N₃O₃ | |
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MLBZKOGAMRTSKP-UHFFFAOYSA-N | |
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Yes |
General status |
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Insecticide, Acaracide | |
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Isoxazoline | |
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Synthetic | |
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Inhibits γ-aminobutyric acid (GABA)-gated chloride channels (GABACls) and Glutamate-gated chloride channel (GluCl) allosteric modulator. | |
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[Ligand-gated chloride channels, Inhibitor] | |
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864731-61-3 | |
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Ectoparasiticide for systemic use | |
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QP53BE02 | |
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No | |
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556.29 | |
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4-(5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl)-2-methyl-n-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)benzamide | |
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White to off-white crystals or powder | |
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Formulations |
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Bravecto Chewable Tablets | MSD Animal Health UK Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Bravecto Spot-on Solution | MSD Animal Health UK Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Bravecto 1000 mg Fluralaner Spot-on | Intervet Australia Pty Ltd | Not licensed | Not licensed | |||||||
Exzolt Pour-on for cattle | - | - | - | |||||||
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Available as tablets and pour-on products |
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3.16 X 1004 | Calculated | - | |||||||
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4.5 | E4 E = Manufacturers safety data sheets 4 = Verified data |
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Degradation |
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60 | E4 E = Manufacturers safety data sheets 4 = Verified data |
Moderately persistent | |||||||
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Stable | E4 E = Manufacturers safety data sheets 4 = Verified data |
Stable | |||||||
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Stable at all environmentally relevant pHs at 25 °C | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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27 | E4 E = Manufacturers safety data sheets 4 = Verified data |
Low potential | |||||||||||||||||||||||||
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No data | - |
Known metabolites |
None
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Terrestrial ecotoxicology |
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> 2000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Low | ||||||||
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0.13 | R4 R = Peer reviewed scientific publications Apis mellifera4 = Verified data |
High | |||||||
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0.13 | R4 R = Peer reviewed scientific publications Apis mellifera4 = Verified data |
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Aquatic ecotoxicology |
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2.0 | E4 E = Manufacturers safety data sheets Cyprinus carpio4 = Verified data |
Moderate | ||||||||
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> 10.0 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Danio rerio4 = Verified data |
Moderate | ||||||||
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> 0.001 | E4 E = Manufacturers safety data sheets Daphnia magna4 = Verified data |
High | ||||||||
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> 10 | E4 E = Manufacturers safety data sheets Raphidocelis subcapitata4 = Verified data |
Low | ||||||||
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General |
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> 2000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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Excretion of unchanged fluralaner occurs in faeces (~90% of the dose) | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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May cause serious eye damage May cause breathing difficulties or asthma symptoms Suspected of causing genetic defects May damage vital organs |
Handling issues |
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No information available | |||
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Health: H315, H317. H318, H334, H335, H341, H361, H371 Environment: H413 |
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Not listed (Not listed) | |||
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Not regulated | |||
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fluralaner | ||
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Record last updated: | 24/07/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |