Afoxolaner |
Last updated: 20/01/2024 |
(Not known by any other names) |
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An isoxazoline drug used to control ectoparasites | |
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Current | |
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2014, EU authorisation for use | |
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Used to control flea and tick infestations as well as demodicosis and sarcoptic mange | |
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Dogs; Cats |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Racemic mixture | |
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C₂₆H₁₇ClF₉N₃O₃ | |
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C1C(=NOC1(C2=CC(=CC(=C2)Cl)C(F)(F)F)C(F)(F)F)C3=CC=C(C4=CC=CC=C43)C(=O)NCC(=O)NCC(F)(F)F | |
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OXDDDHGGRFRLEE-UHFFFAOYSA-N | |
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InChI=1S/C26H17ClF9N3O3/c27-15-8-13(7-14(9-15)25(31,32)33)23(26(34,35)36)10-20(39-42-23)18-5-6-19(17-4-2-1-3-16(17)18)22(41)37-11-21(40)38-12-24(28,29)30/h1-9H,10-12H2,(H,37,41)(H,38,40 | |
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Yes |
General status |
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Insecticide; Acaracide; Antiparasitic | |
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Isoxazoline | |
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Synthetic | |
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Blocks synaptic transfer of choride ions across cell membranes and so distrupts insect nervous system. | |
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[GABA-receptors, Antagonist] | |
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1093861-60-9 | |
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832-051-7 | |
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25154249 | |
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Ectoparasiticides, including insecticides and repellents | |
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QP53BE01 | |
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No | |
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625.88 | |
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4-(5-(3-chloro-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl)-N-(2-oxo-2-(2,2,2-trifluoroethylamino)ethyl)naphthalene-1-carboxamide | |
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4-(5-(3-chloro-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl)-N-(2-oxo-2-(2,2,2-trifluoroethylamino)ethyl)naphthalene-1-carboxamide | |
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4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide | |
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Formulations |
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Nexgard Chewable Tablets | Boehringer Ingelheim Vetmedica GmbH | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Frontpro chewable tablets | Boehringer Ingelheim Vetmedica GmbH | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Normally formulated, alone or in combination with other medications, as chewable tablets or spot-on solutions |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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Aquatic ecotoxicology |
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Primarily excreted via the biliary route in around 12-14 hrs | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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No information available |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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afoxolaner | ||
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Record last updated: | 20/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |