Epinephrine |
Last updated: 23/05/2024 |
(Also known as: adrenaline) |
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Epinephrine is widely used drug for anaphylactoid shock | |
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Current | |
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Primarily used to treat anaphylaxis and for cardiac resuscitation | |
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Dogs; Cats; Other domesticated animals; Cattle; Horses; Pigs; Sheep |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric. The R-enantiomer of epinephrine is the hormone secreted by the adrenal glands. | |
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C₉H₁₃NO₃ | |
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CNCC(C1=CC(=C(C=C1)O)O)O | |
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CNC[C@@H](C1=CC(=C(C=C1)O)O)O | |
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UCTWMZQNUQWSLP-VIFPVBQESA-N | |
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InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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epinephrine | - |
General status |
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Medicinal drug | |
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Hormone | |
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Unclassified medicinal drug; Hornone | |
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Synthetic | |
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Antagonizes the effects of histamine, raises blood sugar, increases heart rate and contractility, and increases systolic blood pressure. | |
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[Adrenergic receptors] | |
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51-43-4 | |
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51028-73-0 | |
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200-098-7 | |
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5816 | |
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Multiple therapeutic classes | |
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QA01AD01; QB02BC09; QC01CA03; QC01CA24; QR01AA14; QR03AA01; QR03AK01; QS01EA01; QS01EA51 | |
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No | |
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183.21 | |
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4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol | |
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4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol | |
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White microcrystalline powder | |
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Formulations |
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Adrenacaine Solution for Injection for Cattle | Norbrook Laboratories Limited | GB National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | ||||||
Tri-solfen Cutaneous Solution | Dechra Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Usually formulated as solutions for injection but also as cutaneous sprays for topical use |
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100 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Moderate | ||||||||
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211.5 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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215 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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4.27 X 10-02 | Calculated | - | |||||||
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-1.37 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Low | ||||||||
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1.28 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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8.59 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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90 | Q3 Q = Miscellaneous data from online sources Mouse3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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90 | Q3 Q = Miscellaneous data from online sources Mouse3 = Unverified data of known source |
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300 | Q3 Q = Miscellaneous data from online sources Mouse3 = Unverified data of known source |
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Excreted rapidly in urine | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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No information available |
Handling issues |
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When heated to decomposition it will emit toxic fumes Combustible IMDG Transport Hazard Class 6.1 |
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Health: H301, H311, H315, H319, H335 | |||
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Not listed (Not listed) | |||
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UN2811 | |||
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Packaging Group II (moderate danger) | |||
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Chemically stable under standard ambient conditions |
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epinephrine | ||
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Record last updated: | 23/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |