Chlortetracycline hydrochloride |
Last updated: 24/05/2024 |
(Also known as: chlortetracycline HCl) |
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Broad spectrum antibiotic and antimicrobial substance isolated from the microorganism (treptomyces aureofaciens) used in veterinary products and for aquaculture | |
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Current | |
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1945, first discovered | |
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Mainly used for the prevention of infections of superficial traumatic or surgical wounds | |
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Agricultural livestock including: Poultry, Pigs, Cattle and Fish |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₂₂H₂₄Cl₂N₂O₈ | |
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CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C(C=CC(=C41)Cl)O)O)O)O)C(=O)N)N(C)C)O.Cl | |
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C[C@@]1(C2C[C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C(C=CC(=C41)Cl)O)O)O)O)C(=O)N)N(C)C)O.Cl | |
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QYAPHLRPFNSDNH-LYNLVHCPSA-N | |
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InChI=1S/C22H23ClN2O8.ClH/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21;/h4-5,7-8,15,26-27,30,32-33H,6H2,1-3H3,(H2,24,31);1H/t7?,8-,15-,21-,22-;/m0./s1 | |
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Yes |
General status |
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Medicinal drug, Bactericide, Antimicrobial, Medicated feed additive | |
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Wood preservative, Antimicrobial, Bactericide | |
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Amide pesticide; Tetracycline compound | |
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Natural | |
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Protein synthesis inhibitor | |
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[16S ribosomal RNA, Inhibitor], [30S ribosomal proteins, Inhibitor], [ADP-ribosylation factor 1, Inhibitor], [Catalase, Inhibitor], [Ephrin type-B receptor 1, Inhibitor], [Pancreatic triacylglycerol lipase, Inhibitor], [Protein-arginine deiminase type-4, Inhibitor] | |
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64-72-7 | |
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3671-08-7 | |
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200-591-7 | |
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006301 | |
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54684459 | |
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Dermatologicals: Antibiotics & chemotherapeutics for dermatological use | |
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QD06AA52 | |
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No | |
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Allowed substance (Table 1: All food producing species) | |
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515.3 | |
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- | |
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(4S,4aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride | |
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Possible groundwater contaminant | |
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Formulations |
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Aurofac Granular 100mg/g premix medicated feed | Zoetis UK Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Animedazon Spray | aniMedica GmbH | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Chlorsol Powder | Vetoquinon UK Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Ophtocycline Eye Ointment | LeVet Beheer B.V | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Available in a variety of formulations including medicated premix feed, cutaneous sprays, ointments, cutaneous sprays and powders for oral administration |
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630 | R4 R = Peer reviewed scientific publications 4 = Verified data |
High | ||||||||
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168.5 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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2.40 X 10-01 | Calculated | - | |||||||
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-0.62 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low | ||||||||
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4.5 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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2.09 X 10-23 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Low volatility | ||||||||
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4.8 X 10-22 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Non-volatile | ||||||||
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Substance may enter the environment via the faeces of treated animals or by leaching from spilt medicated feed. |
Degradation |
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30 | R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
Moderately persistent | |||||||
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General literature DT₅₀ range >30 days (R3) | ||||||||||
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44% lost after 30 days | R3 R = Peer reviewed scientific publications Soil and poultry manure at 30°C decreases with decreasing temp3 = Unverified data of known source |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Low risk | Q3 Q = Miscellaneous data from online sources Based on LogP < 33 = Unverified data of known source |
Low risk | |||||||||||||||||||||||||
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 1500 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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> 0.89 | R4 R = Peer reviewed scientific publications Unknown species4 = Verified data |
Moderate | ||||||||
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128 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna3 = Unverified data of known source |
Low | ||||||||
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1.62 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Lemna gibba3 = Unverified data of known source |
Moderate | ||||||||
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3.1 | R3 R = Peer reviewed scientific publications Pseudokirchneriella subcapitata3 = Unverified data of known source |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 1500 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Mouse3 = Unverified data of known source |
Moderate | ||||||||
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Intraperitoneal LDLo = 335 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Intravenous LD₅₀ = 118 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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Mainly eliminated in the faeces | R4 R = Peer reviewed scientific publications 4 = Verified data |
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Health issues |
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No further information available |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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chlortetracycline hydrochloride | ||
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Record last updated: | 24/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |