Chlortetracycline calcium complex |
Last updated: 24/05/2024 |
(Also known as: chlortetracycline calcium; calcium-chlortetracycline complex) |
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Broad spectrum antibiotic and antimicrobial substance isolated from the microorganism (treptomyces aureofaciens) used in veterinary products and for aquaculture. Usually formulated as the hydrochloride salt. | |
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Current | |
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1945, first discovered | |
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Mainly used for the prevention of infections of superficial traumatic or surgical wounds | |
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Agricultural livestock including: Poultry, Pigs, Cattle and Fish |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₄₄H₄₄CaCl₂N₄O₁₆ | |
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[Ca++].[H][C@@]12C[C@@]3([H])C(=C(O)[C@]1(O)C(=O)C(C(N)=O)=C([O-])[C@H]2N(C)C)C(=O)C1=C(C(Cl)=CC=C1O)[C@@]3(C)O.[H][C@@]12C[C@@]3([H])C(=C(O)[C@]1(O)C(=O)C(C(N)=O)=C([O-])[C@H]2N(C)C)C(=O)C1=C(C(Cl)=CC=C1O)[C@@]3(C)O | |
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BRXWPGYMDYZZNU-NAUDNZITSA-L | |
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InChI=1S/2C22H23ClN2O8.Ca/c2*1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21;/h2*4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31);/q;;+2/p-2/t2*7-,8-,15-,21-,22-;/m00./s1 | |
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Yes |
General status |
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Medicinal drug, Bactericide, Antimicrobial, Medicated feed additive | |
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Wood preservative, Antimicrobial, Bactericide | |
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Amide pesticide; Tetracycline compound; Calcium ionophore | |
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Natural | |
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Protein synthesis inhibitor | |
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[16S ribosomal RNA, Inhibitor], [30S ribosomal proteins, Inhibitor], [ADP-ribosylation factor 1, Inhibitor], [Catalase, Inhibitor], [Ephrin type-B receptor 1, Inhibitor], [Pancreatic triacylglycerol lipase, Inhibitor], [Protein-arginine deiminase type-4, Inhibitor] | |
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57122-99-3 | |
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483928915 | |
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Dermatologicals: Antibiotics & chemotherapeutics for dermatological use | |
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QD06AA52 | |
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No | |
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Allowed substance (Table 1: All food producing species) | |
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995.83 | |
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calcium bis((1S,4aS,11S,11aS,12aS)-3-carbamoyl-10-chloro-1-(dimethylamino)-4a,5,7,11-tetrahydroxy-11-methyl-4,6-dioxo-1,4,4a,6,11,11a,12,12a-octahydrotetracen-2-olate) | |
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Possible groundwater contaminant | |
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Beige coloured powder | |
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Formulations |
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Available in a variety of formulations as the hydrochlroide salt including medicated premix feed, cutaneous sprays, ointments, cutaneous sprays and powders for oral administration |
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Substance may enter the environment via the faeces of treated animals. Identified in pig manure at high concentrations implying manure implying a major release route |
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44% lost after 30 days | R3 R = Peer reviewed scientific publications Soil and poultry manure at 30°C decreases with decreasing temp. DT₅₀ range 0.1-56 days3 = Unverified data of known source |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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> 3000 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 3000 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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Mainly eliminated in the faeces | R4 R = Peer reviewed scientific publications 4 = Verified data |
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Health issues |
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Inhalation of dust may cause asthmatic symptoms Possible blood toxin |
Handling issues |
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Avoid generation of dusts | |||
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Not listed (Not listed) | |||
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chlortetracycline calcium complex | ||
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Record last updated: | 24/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |