Albendazole sulfoxide |
Last updated: 22/05/2024 |
(Also known as: albendazole oxide) |
SUMMARY |
A potent anthelmintic insecticide. It has a low aqueous solubility. Little has been published regarding its behaviour in the environment or its toxicity to fauna and flora. It is moderately toxic to humans and may cause reproduction or fertility problems. . |
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A broad spectrum benzimidazole antiparasitic veterinary drug | |
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Current | |
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1977, introduced UK | |
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Primary use is as a topical pesticide for livestock for control of parasites in particular various worm infestations. | |
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Domestic and farm animals including cattle & sheep |
Approval status |
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Approved | |
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Chemical structure |
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C₁₂H₁₅N₃O₃S | |
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CCCS(=O)C1=CC2=C(C=C1)N=C(N2)NC(=O)OC | |
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VXTGHWHFYNYFFV-UHFFFAOYSA-N | |
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InChI=1S/C12H15N3O3S/c1-3-6-19(17)8-4-5-9-10(7-8)14-11(13-9)15-12(16)18-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16) | |
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Yes |
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Common Name | Relationship | Link |
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albendazole | Parent |
General status |
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Insecticide, Antiparasitic, Anthelmintic | |
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Mammal | |
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Benzimidazole | |
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Natural | |
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Causes degenerative alterations in parasite cell walls, inhibiting tubulin polymerization which results in the loss of cytoplasmic microtubules. | |
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[Tubulin alpha-3 chain, Antagonist], [Tubulin beta-2C chain, Antagonist], [Fumarate reductase flavoprotein subunit, Antagonist] | |
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54029-12-8 | |
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122063-18-7 | |
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628-805-8 | |
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None allocated | |
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83969 | |
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Antiparasitic products, insecticides & repellents: Anthelmintics | |
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QP52AC11 | |
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No | |
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Allowed substance (Table 1: Ruminants) | |
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281.33 | |
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methyl N-(6-propylsulfinyl-1H-benzimidazol-2-yl)carbamate | |
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methyl N-(6-propylsulfinyl-1H-benzimidazol-2-yl)carbamate | |
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Formulations |
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Environmental release can occur via four main routes (i) point source releases at production sites, (ii) releases at administration location, (iii) direct releases from treated animals as parent and metabolites in manure and slurries, and (iv) inappropriate waste disposal sites |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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Aquatic ecotoxicology |
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General |
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Rapidly metabolised and lost via (probably) biliary excretion. Little is found in the urine. | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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Mutagenic potential Possible tetragenic effect Possible liver toxicant |
Handling issues |
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No information available | |||
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Health: H302, H317, H361d, H371, H373 Environment: H400, H410 |
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Not listed (Not listed) | |||
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albendazole sulfoxide | ||
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Record last updated: | 22/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |