Albendazole |
Last updated: 02/05/2024 |
(Also known as: SLA 3505; SKF-62979) |
SUMMARY |
A potent anthelmintic insecticide. It has a low aqueous solubility. Little has been published regarding its behaviour in the environment or its toxicity to fauna and flora. It is moderately toxic to humans and may cause reproduction or fertility problems. . |
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A broad spectrum benzimidazole antiparasitic veterinary drug | |
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Current | |
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1977, registered UK | |
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Primary use is as a topical pesticide for livestock for control of parasites in particular various worm infestations. | |
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Domestic and farm animals including cattle & sheep |
Approval status |
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Approved | |
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Chemical structure |
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C₁₂H₁₅N₃O₂S | |
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CCCSC1=CC2=C(C=C1)N=C(N2)NC(=O)OC | |
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HXHWSAZORRCQMX-UHFFFAOYSA-N | |
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InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16) | |
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Yes |
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Common Name | Relationship | Link |
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albendazole | - |
General status |
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Insecticide, Antiparasitic, Anthelmintic | |
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Benzimidazole insecticide | |
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>98% | |
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Synthetic | |
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Causes degenerative alterations in parasite cell walls, inhibiting tubulin polymerization which results in the loss of cytoplasmic microtubules. | |
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[Tubulin alpha-3 chain, Antagonist], [Tubulin beta-2C chain, Antagonist], [Fumarate reductase flavoprotein subunit, Antagonist] | |
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54965-21-8 | |
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259-414-7 | |
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None allocated | |
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2082 | |
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Antiparasitic products, insecticides & repellents: Anthelmintics | |
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QP52AC11 | |
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No | |
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Allowed substance (Table 1: Ruminants) | |
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265.33 | |
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methyl N-(6-propylsulfanyl-1H-benzimidazol-2-yl)carbamate | |
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5-(propylthio)-1H-benzimidazol-2-yl, methyl ester carbamic acid | |
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Off-white crystalline powder | |
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Formulations |
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Albenil 2.5% SC Oral Suspension | Virbac Ltd | UK National authorisation (IC) | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | ||||||
Albacert Oral suspension | Chanelle Animal Health Ltd | UK National authorisation (IC) | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
Endospec SC Oral Suspension | Bimeda Animal Health Ltd | UK National authorisation | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
Tramazole Oral Suspension | Tulivin Labs | UK National authorisation (IC) | Prescription only medicine to be authorised by suitably qualified person (POM-VPS) | |||||||
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Usually supplied as a solution for oral use |
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0.56 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Low | ||||||||
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209 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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1.86 X 1001 | Calculated | - | |||||||
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1.27 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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10.26 | R4 R = Peer reviewed scientific publications 4 = Verified data |
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pKa(2) = 2.80 | |||||||||||
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Environmental release can occur via four main routes (i) point source releases at production sites, (ii) releases at administration location, (iii) direct releases from treated animals as parent and metabolites in manure and slurries, and (iv) inappropriate waste disposal sites |
Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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- | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Non-mobile | |||||||
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17650 | ||||||||||
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Literature range 7800-27500 | ||||||||||
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251 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Non-mobile | |||||||
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16233 | ||||||||||
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0.92 | ||||||||||
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US data: Kf range 109.6-501.2 mL g⁻¹, Kfoc range 7800-27500 mL g⁻¹, 1/n range 0.77-1.21, Soils=3 | ||||||||||
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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albendazole sulfoxide Note: C12H15N3O3S |
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albendazole sulfone Note: C12H15N3O4S |
- | Human (Liver); Livestock | - |
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Terrestrial ecotoxicology |
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1320 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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86.0 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Oncorhynchus mykiss3 = Unverified data of known source |
Moderate | ||||||||
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> 0.036 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Danio rerio EC₅₀ Embryo3 = Unverified data of known source |
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0.024 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna3 = Unverified data of known source |
High | ||||||||
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0.017 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna3 = Unverified data of known source |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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1320 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
Moderate | ||||||||
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Intravenous LD₅₀ = 265 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
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0.005 | Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source |
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Rapidly metabolised and lost via (probably) biliary excretion. Little is found in the urine. | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Health issues |
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Mutagenic potential Possible tetragenic effect Possible liver toxicant |
Handling issues |
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No information available | |||
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Health: H315, H319, H335, H360, H361 Environment: H400, H410 |
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Not listed (Not listed) | |||
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albendazole | ||
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albendazole | ||
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Albendazol | ||
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albendazol | ||
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albendazol | ||
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Record last updated: | 02/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |