Procaine benzylpenicillin |
Last updated: 24/07/2024 |
(Also known as: penicillin G procaine) |
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A combination of benzylpenicillin with the local anaesthetic agent procaine used as an anesthetic | |
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Current | |
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Used as a local anaesthetic for minor surgical procedures on a variety of animals | |
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Cattle; Sheep; Goats, Horses; Pigs; Dogs; Cats |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₂₉H₃₈N₄O₆S | |
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CCN(CC)CCOC(=O)C1=CC=C(C=C1)N.CC1(C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CC=C3)C(=O)O)C | |
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CCN(CC)CCOC(=O)C1=CC=C(C=C1)N.CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)CC3=CC=CC=C3)C(=O)O)C | |
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WHRVRSCEWKLAHX-LQDWTQKMSA-N | |
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InChI=1S/C16H18N2O4S.C13H20N2O2/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);5-8H,3-4,9-10,14H2,1-2H3/t11-,12+,14-;/m1./s1 | |
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Yes |
General status |
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Anesthetic, Medicinal drug | |
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Aminobenzoate | |
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Synthetic | |
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Sodium channel modulator. | |
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[Sodium channel protein type 10 subunit alpha, Antagonist], [Glutamate [NMDA] receptor subunit 3A, Antagonist], [5-hydroxytryptamine 3 receptor, Antagonist], [Sodium-dependent dopamine transporter, Antagonist], [Neuronal acetylcholine receptor subunit alpha-2, Antagonist] | |
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54-35-3 | |
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5903 | |
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Nervous system: Anaesthetic | |
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QN01BA52 | |
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Allowed susbstance (Table 1: All food producing species) | |
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570.7 | |
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2-(diethylamino)ethyl 4-aminobenzoate;(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid | |
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Formulations |
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Bimprocil Suspenssion for Injection | Bimeda Animal Health Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Depocillin Suspension for Injection | MSD Animal Health UK Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Nafpenzal Dry Cow | MSD Animal Health UK Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Ultrapen LA Suspension for Injection | Norbrook Labortories Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Usually formulated as a solution for injection |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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200 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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200 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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Majority is metabolised and the metabolised are rapidly (in minutes) excreted mostly in the urine | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May cause cardiac and vasodilation effects May cause serious allergic reactions Harmful if swallowed |
Handling issues |
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When heated to decomposition it emits toxic fumes of nitroxides IMDG Transport Hazard Class 6.1 Hygroscopic in air |
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Not listed (Not listed) | |||
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UN2811 | |||
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Packaging Group III (minor danger) | |||
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procaine benzylpenicillin | ||
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Record last updated: | 24/07/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |