Pyrantel |
Last updated: 22/01/2024 |
(Not known by any other names) |
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A tetrahydropyrimidine veterinary anthelmintic drug | |
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Current | |
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Used as a deworming agent in the treatment of hookworms, roundworms and gastric parasitic worms | |
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Horses; Ponies; Cattle; Sheep; Pigs; Cats; Dogs |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₁₁H₁₄N₂S | |
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CN1CCCN=C1C=CC2=CC=CS2 | |
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CN1CCCN=C1/C=C/C2=CC=CS2 | |
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YSAUAVHXTIETRK-AATRIKPKSA-N | |
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InChI=1S/C11H14N2S/c1-13-8-3-7-12-11(13)6-5-10-4-2-9-14-10/h2,4-6,9H,3,7-8H2,1H3/b6-5+ | |
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Yes |
General status |
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Anthelmintic, Antiparasitic, Nematicide | |
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Tetrahydropyrimidine | |
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Synthetic | |
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Acts as a potent agonist at the acetylcholine receptors on the muscle cells of nematodes causing paralysis. | |
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[Nicotinic acetylcholine receptor, Agonist] | |
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15686-83-6 | |
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239-774-1 | |
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Antiparasitic products, insecticides & repellents: Ectoparasiticides | |
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QP52CC01 | |
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Allowed substance (Table 1: Equidae) | |
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206.31 | |
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1-methyl-2-[(E)-2-thiophen-2-ylethenyl]-5,6-dihydro-4H-pyrimidine | |
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Formulations |
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Molecare Dog Wormer Tablets | C&H Generics Lts | UK National authorisation | For non-food animal use and may be supplied without a prescription by a suitable qualified person (NFA-VPS) | ||||||
PrazitelPlus Tablets | Chanelle Pharmaceuticals Manufacturing Ltd | UK National authorisation | For non-food animal use and may be supplied without a prescription by a suitable qualified person (NFA-VPS) | |||||||
Pro-Tel Flavoured Tablets | Ceva Animal Health Ltd | GB National authorisation | For non-food animal use and may be supplied without a prescription by a suitable qualified person (NFA-VPS) | |||||||
Quantilex Plus Tablets for dogs | Chanelle Pharmaceuticals Manufacturing Ltd | UK National authorisation | For non-food animal use and may be supplied without a prescription by a suitable qualified person (NFA-VPS) | |||||||
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Usually formulated for oral administration as tablets and oral pastes |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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> 2000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 2000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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Mainly excreted via the faeces | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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May cause gastrointestinal effects such as nausea and vomiting, anorexia, abdominal pain and diarrhoea |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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pyrantel | ||
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pyrantel | ||
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pyranteli | ||
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pirantel | ||
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Record last updated: | 22/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |