Amantadine sulphate |
Last updated: 09/02/2024 |
(Also known as: amantadine sulfate) |
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A veterinary drug used as an antiviral agent and/or as pain relief often used in conjunction with NSAIDs or opiods | |
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Current | |
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1966, first introduced USA as human drug to treat Asian influenza | |
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Used as an antiviral agent and/or as pain relief caused by conditions such as arthritis and cancer | |
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Dogs; Cats |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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C₂₀H₃₆N₂O₄S | |
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C1C2CC3CC1CC(C2)(C3)N.C1C2CC3CC1CC(C2)(C3)N.OS(=O)(=O)O | |
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MYWTWSQFJLXGGQ-UHFFFAOYSA-N | |
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InChI=1S/2C10H17N.H2O4S/c2*11-10-4-7-1-8(5-10)3-9(2-7)6-10;1-5(2,3)4/h2*7-9H,1-6,11H2;(H2,1,2,3,4) | |
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Common Name | Relationship | Link |
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amantadine | Parent |
General status |
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Medicinal drug: Antiviral agent, Pain relief | |
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Unclassified substance | |
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Synthetic | |
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Inhibits viral replication by interfering with an integral membrane protein | |
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[Matrix protein 2, Inhibitor], [Glutamate receptor ionotropic, NMDA 3A, Antagonist], [D(2) dopamine receptor, Agonist], [Aromatic-L-amino-acid decarboxylase, Inducer] | |
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31377-23-8 | |
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250-604-5 | |
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124108 | |
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Nervous system: Adamantane derivatives | |
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QN04BB01 | |
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No | |
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400.60 | |
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1-aminoadamantane sulphate | |
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adamantan-1-amine; sulfuric acid | |
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White fine crystalline powder | |
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Formulations |
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Symmetrel | Endo Pharmaceuticals | Not licensed | Not licensed | ||||||
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300 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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225.7 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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890 | E4 E = Manufacturers safety data sheets Ra4 = Verified data |
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Aquatic ecotoxicology |
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> 22.6 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Pimephales promelas4 = Verified data |
Moderate | ||||||||
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> 17.4 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna4 = Verified data |
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General |
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890 | E4 E = Manufacturers safety data sheets Ra4 = Verified data |
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Rapidly and almost completely absorbed from gastrointestinal tract. Unmetabolised renal elimination (90%) | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Health issues |
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May cause nervousness, irritability, or insomnia, and possibly seizures May cause nausea, constipation or diarrhoea, dry mouth, and loss of appetite May cause serious eye and skin damage if in contact |
Handling issues |
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Hygroscopic Corrosive |
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Health: H302, H315, H319, H335, H361 Environment: H412 |
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Not listed (Not listed) | |||
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amantadine sulphate | ||
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Record last updated: | 09/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |