Amantadine hydrochloride |
Last updated: 09/02/2024 |
(Also known as: 1-aminoadamantane HCl; amantadine HCl) |
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A veterinary drug used as an antiviral agent and/or as pain relief often used in conjunction with NSAIDs or opiods | |
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Current | |
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1966, first introduced USA as human drug to treat Asian influenza | |
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Used as an antiviral agent and/or as pain relief caused by conditions such as arthritis and cancer | |
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Dogs; Cats |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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C₁₀H₁₈ClN | |
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C1C2CC3CC1CC(C2)(C3)N.Cl | |
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WOLHOYHSEKDWQH-UHFFFAOYSA-N | |
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InChI=1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H | |
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Yes |
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Common Name | Relationship | Link |
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amantadine | Parent |
General status |
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Medicinal drug: Antiviral agent, Pain relief | |
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Unclassified substance | |
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Synthetic | |
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Inhibits viral replication by interfering with an integral membrane protein | |
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[Matrix protein 2, Inhibitor], [Glutamate receptor ionotropic, NMDA 3A, Antagonist], [D(2) dopamine receptor, Agonist], [Aromatic-L-amino-acid decarboxylase, Inducer] | |
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665-66-7 | |
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211-560-2 | |
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64150 | |
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Nervous system: Adamantane derivatives | |
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QN04BB01 | |
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No | |
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187.71 | |
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1-aminoadamantane hydrochloride | |
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adamantan-1-amine; hydrochloride | |
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White powdery solid | |
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Formulations |
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6290 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
High | ||||||||
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360 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
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160 | E3 E = Manufacturers safety data sheets (open cup)3 = Unverified data of known source |
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2.51 X 1002 | Calculated | - | |||||||
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2.4 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
Low | ||||||||
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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800 | E4 E = Manufacturers safety data sheets Rat4 = Verified data |
Moderate | ||||||||
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Aquatic ecotoxicology |
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> 51.0 | E3 E = Manufacturers safety data sheets Unknown species3 = Unverified data of known source |
Moderate | ||||||||
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24.4 | E3 E = Manufacturers safety data sheets Daphnia magna3 = Unverified data of known source |
Moderate | ||||||||
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General |
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800 | E4 E = Manufacturers safety data sheets Rat4 = Verified data |
Moderate | ||||||||
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Acute, intraperitoneal LD₅₀ = 180 mg kg⁻¹ | E4 E = Manufacturers safety data sheets Rat4 = Verified data |
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Rapidly and almost completely absorbed from gastrointestinal tract. Unmetabolised renal elimination (90%) | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Health issues |
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May cause nervousness, irritability, or insomnia, and possibly seizures May cause nausea, constipation or diarrhoea, dry mouth, and loss of appetite May cause serious eye and skin damage if in contact |
Handling issues |
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Dust could form explosive mixtures with air Corrosive and toxic gases may be released on heating Incompatible with oxidising agents, strong acids. & strong bases IMDG Transport Hazard Class 8 |
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Health: H302, H314, H318, H335, H361fd Environment: H412 |
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Not listed (Not listed) | |||
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UN3261 | |||
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Packaging group II (moderate danger) | |||
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amantadine hydrochloride | ||
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Record last updated: | 09/02/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |