DDE (Ref: HSDB 1625) |
Last updated: 26/08/2024 |
(Also known as: dichlorodiphenyldichloroethylene; DDT dehydrochloride; p,p'-DDE) |
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Chemical transformation product formed by the dehydrohalogenation of DDT. Has insecticidal properties but no significant commercial applications. | |
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Not applicable | |
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Not applicable | |
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Approval status |
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Chemical structure |
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Consists of three isomeric forms p,p'-DDE, o,p'-DDE and o,o'-DDE. p,p'-DDE is the dominant isomer. | |
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C₁₄H₈Cl₄ | |
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C1=CC(=CC=C1C(=C(Cl)Cl)C2=CC=C(C=C2)Cl)Cl | |
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No data | |
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UCNVFOCBFJOQAL-UHFFFAOYSA-N | |
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InChI=1S/C14H8Cl4/c15-11-5-1-9(2-6-11)13(14(17)18)10-3-7-12(16)8-4-10/h1-8H | |
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Yes |
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Common Name | Relationship | Link |
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DDE | - |
General status |
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Soil, Groundwater | |
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Organochloride substance | |
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Synthetic | |
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Central nervous system stimulant. GABA-gated chloride channel antagonist. A weak androgen receptor antagonist. | |
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72-55-9 | |
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200-784-6 | |
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292 | |
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3035 | |
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318.02 | |
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1,1-bis-(4-chlorophenyl)-2,2-dichloroethene | |
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1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene | |
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OSPAR soc, Banned; Hazardous air pollutant | |
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White crystalline solid |
Can be a metabolite of: |
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O,O'-DDT | Soil | - | - | |||||
O,O'-DDT | Groundwater | - | Relevancy unknown | |||||
O,P'-DDT | Soil | - | - | |||||
O,P'-DDT | Groundwater | - | Relevancy unknown | |||||
lindane | Soil | - | - | |||||
DDT | Soil | - | - | |||||
DDT | Groundwater | - | Relevancy unknown | |||||
P,P'-DDT | Soil | - | - | |||||
P,P'-DDT | Groundwater | - | Relevancy unknown |
Formulations |
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0.12 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low | ||||||||
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89 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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336 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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3.24 X 1006 | Calculated | - | |||||||
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6.51 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
High | ||||||||
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Likely to be soluble | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Based on chemical group | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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1.402 | Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source |
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Not applicable | R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
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No dissociation | |||||||||||
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Degradation |
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5000 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Very persistent | |||||||
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5000 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Very persistent | ||||||||
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Environmentally stable | ||||||||||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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50000 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Log Koc given as 4.7 | ||||||||||
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Fate indices |
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1800 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Oncorhynchus mykiss4 = Verified data |
Threshold for concern | |||||||||||||||||||||||||
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Not available | - |
Known soil and groundwater metabolites |
None
Other known metabolites |
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1-chloro-2,2-bis(p-chlorophenyl)ethylene | DDMU | Humans; Rats | - | ||||
2,2-bis(bis(p-chlorophenyl)ethylene | DDNU | Humans; Rats | - | ||||
2,2-bis(p-chlorophenyl)acetaldehyde | DDCHO | Humans; Rats | - | ||||
2,2-bis(p-chlorophenyl)acetic acid | DDA | Humans; Rats | - |
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Terrestrial ecotoxicology |
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880 | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat3 = Unverified data of known source |
Moderate | ||||||||
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825 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Colinus virginianus4 = Verified data |
Moderate | ||||||||
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61 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Lumbricus terrestris3 = Unverified data of known source |
Moderate | ||||||||
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Aquatic ecotoxicology |
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== 0.032 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Oncorhynchus mykiss4 = Verified data |
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0.001 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) Bosmina longirostris3 = Unverified data of known source |
High | ||||||||
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General |
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High (class III) | - | - | ||||||||
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880 | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat3 = Unverified data of known source |
Moderate | ||||||||
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List I | - | - | ||||||||
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DDE is mainly excreted in the bile. Excretion is slow with a biologic half-life of about 8 yr. | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Health issues |
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Toxic if ingested, inhaled and via skin absorption Xenoestrogen agent Mutagenic Endocrine issues - Competitive binding to androgen receptors US EPA - probable human carcinogen |
Handling issues |
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P,P'-DDE is sensitive to exposure to light Incompatible with strong oxidising substances and strong bases IMDG Transport Hazard Class 6.1 |
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Health: H302, H311, H315, H331, H332 Environment: H400, H410 |
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Not listed (Not listed) | |||
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UN2761 | |||
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DDE | ||
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dichlorodifenylodichloroetylen | ||
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Record last updated: | 26/08/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |