Streptomycin |
Last updated: 24/08/2024
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(Also known as: streptomycine; streptamine; streptomycin A ; Crop antibiotic) |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate |
Ecotoxicity |
Human health |
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Streptomycin is used to combat the growth of bacteria, fungi, and algae on a wide range of crops. It also has applications as a drug specifically as a bactericidal antibiotic. |
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Bacterial shot-hole; Bacterial rots; Bacterial canker; Bacterial wilts; Fire blight |
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Top fruit; Stone fuit; Citrus; Olives; Vegetables; Potatoes; Tobacco; Ornamentals |
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- |
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- |
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1944, first reported; 1958, commericalised USA |
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- |
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Not approved |
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Not applicable |
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No UK approval for use |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved |
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Not applicable |
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Not applicable |
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Not applicable |
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Yes |
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ATAustria |
BEBelgium |
BGBulgaria |
CYCyprus |
CZCzech Republic |
DEGermany |
DKDenmark |
EEEstonia |
ELGreece |
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ESSpain |
FIFinland |
FRFrance |
HRCroatia |
HUHungary |
IEIreland |
ITItaly |
LTLithuania |
LULuxembourg |
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LVLatvia |
MTMalta |
NLNetherlands |
PLPoland |
PTPortugal |
RORomania |
SESweden |
SISlovenia |
SKSlovakia |
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ISIceland |
NONorway |
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A chiral molecule |
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C₂₁H₃₉N₇O₁₂ |
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CC1C(C(C(O1)OC2C(C(C(C(C2O)O)N=C(N)N)O)N=C(N)N)OC3C(C(C(C(O3)CO)O)O)NC)(C=O)O |
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C[C@@H]1[C@]([C@@H]([C@H](O1)O[C@@H]2[C@H]([C@@H]([C@H]([C@@H]([C@H]2O)O)N=C(N)N)O)N=C(N)N)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)NC)(C=O)O |
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UCSJYZPVAKXKNQ-APUVXCOVSA-N |
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InChI=1S/C21H39N7O12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35/h4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28)/t5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+/m1/s1 |
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Yes |
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Fungicide, Veterinary substance, Crop antibiotic, Other substance |
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Other substance |
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Micro-organism |
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- |
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- |
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Natural |
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A aminoglycoside that inhibites protein biosynthesis, systemic action |
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Isolated from the soil actinomycete, Streptomyces griseus |
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Commerically, streptomycin is produced uses a fermentation process based on Streptococcus griseus together with a natural source of carbon and nitrogen, and a growth stimulating compound |
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Crop protection |
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Bacterial shot-hole; Bacterial rots; Bacterial canker; Bacterial wilts; Fire blight |
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Top fruit; Stone fuit; Citrus; Olives; Vegetables; Potatoes; Tobacco; Ornamentals |
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- |
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57-92-1 |
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200-355-3 |
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312 |
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006306 |
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19649 |
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581.57 |
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- |
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O-2-deoxy-2-methylamino-α-L-glucopyranosyl-(1-2)-O-5-deoxy-3-C-formyl-α-L-lyxofuranosyl-(1-4)-N1,N3-diamidino-D-streptamine |
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O-2-deoxy-2-(methylamino)-α-L-glucopyranosyl-(1-2)-O-5-deoxy-3-C-formyl-α-L-lyxofuranosyl-(1-4)-N,N'-bis(aminoiminomethyl)-D-streptamine |
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- |
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- |
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Not applicable |
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Not applicable |
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Not applicable |
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BM02 |
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Resistance is widespread |
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White powder |
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Plantomycin |
Aries agro Ltd |
Agrimycin 17 |
Nufarm Ltd |
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It is available as a water soluble powder, pellets or as an emulsifiable concentrate. Applied as a foliar spray for crop protetcion. |
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1000000 |
at 25 °C |
High |
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12 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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3.16 X 10-08 |
Calculated |
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-7.5 |
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Low |
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n/a |
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7.76 X 10-23 |
at 25 °C |
Low volatility |
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8.52 X 10-39 |
at 25 °C |
Non-volatile |
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- |
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1.0 |
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Non-persistent |
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- |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. |
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Soil adsorption and mobility |
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Moderately mobile |
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339 |
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None
Terrestrial ecotoxicology |
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> 9000 |
Rat |
Low |
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> 4640 |
E4 E = Manufacturers safety data sheets 4 = Verified data Anas platyrhynchos |
Low |
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> 180 |
E4 E = Manufacturers safety data sheets 4 = Verified data Oncorhynchus mykiss |
Low |
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487 |
R4 R = Peer reviewed scientific publications 4 = Verified data Daphnia magna |
Low |
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0.133 |
R4 R = Peer reviewed scientific publications 4 = Verified data Pseudokirchneriella subcapitata |
Moderate |
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HUMAN HEALTH AND PROTECTION |
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High (class III) |
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> 9000 |
Rat |
Low |
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325 |
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source Mouse |
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Intraperitoneal LD₅₀ = 525 mg kg⁻¹ |
Mouse |
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Intravenous LDLo = 175 mg kg⁻¹ |
Rat |
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Majority of oral dose is excreted in the faeces. Parenteral administration leads to urinal elimination. |
R4 R = Peer reviewed scientific publications 4 = Verified data |
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Carcinogen |
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Endocrine disruptor |
No data found |
A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data |
No data found |
Reproduction / development effects |
Acetyl cholinesterase inhibitor |
Neurotoxicant |
?Possibly, status not identified |
No data found |
?Possibly, status not identified |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
No data found |
?Possibly, status not identified |
?Possibly, status not identified |
Eye irritant |
Phototoxicant |
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?Possibly, status not identified |
No data found |
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May cause rashes, hives, headache, drop in blood pressure, nausea and vomiting Possible kidney toxicant May cause hearing dysfunction |
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No information available |
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Not listed (Not listed) |
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streptomycin |
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streptomycine |
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Streptomyzin |
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streptomicina |
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estreptomicina |
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Record last updated: |
24/08/2024 |
Contact: |
aeru@herts.ac.uk |
Please cite as: |
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |