Brucine |
Last updated: 30/08/2024
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(Also known as: Brucinium) |
Brucine is a highly toxic alkaloid substance that was used as a rodenticide. Little information is available regarding its environmental fate or its toxicology. |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate |
Ecotoxicity |
Human health |
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An alkaloid substance used as a rodenticide similar to strychnine but less potent |
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Rats; Mice; Rodents; Birds; Moles |
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Agricultural situations |
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Considered obsolete but may be available in some countries |
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Not approved |
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Not applicable |
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No UK approval for use |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved |
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Not applicable |
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Not applicable |
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Not applicable |
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No |
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ATAustria |
BEBelgium |
BGBulgaria |
CYCyprus |
CZCzech Republic |
DEGermany |
DKDenmark |
EEEstonia |
ELGreece |
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ESSpain |
FIFinland |
FRFrance |
HRCroatia |
HUHungary |
IEIreland |
ITItaly |
LTLithuania |
LULuxembourg |
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LVLatvia |
MTMalta |
NLNetherlands |
PLPoland |
PTPortugal |
RORomania |
SESweden |
SISlovenia |
SKSlovakia |
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ISIceland |
NONorway |
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Isomeric |
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C₂₃H₂₆N₂O₄ |
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COC1=C(C=C2C(=C1)C34CCN5C3CC6C7C4N2C(=O)CC7OCC=C6C5)OC |
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COC1=C(C=C2C(=C1)[C@]34CCN5[C@H]3C[C@@H]6[C@@H]7[C@@H]4N2C(=O)C[C@@H]7OCC=C6C5)OC |
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RRKTZKIUPZVBMF-IBTVXLQLSA-N |
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InChI=1S/C23H26N2O4/c1-27-16-8-14-15(9-17(16)28-2)25-20(26)10-18-21-13-7-19-23(14,22(21)25)4-5-24(19)11-12(13)3-6-29-18/h3,8-9,13,18-19,21-22H,4-7,10-11H2,1-2H3/t13-,18-,19-,21-,22-,23+/m0/s1 |
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Yes |
Cambridge Crystallographic Data Centre diagrams |
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Common Name |
Relationship |
Link |
brucine |
Unstated isomer |
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Rodenticide |
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Plant-derived substance; Alkaloid compound |
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Natural |
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Brucine was also extracted, along with strychnine,from the seeds of Strychnos nuxvomica |
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A toxic plant alkaloid extracted from seeds of Strychnos or Loganiaceae spp. found predominately in southern Asia |
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Pest control |
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Rats; Mice; Rodents; Birds; Moles |
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357-57-3 |
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206-614-7 |
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None allocated |
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442021 |
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614-007-00-7 |
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394.51 |
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(4aR,5aS,8aR,13aS,15aS,15bR)-10,11-dimethoxy-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinoline-14-one |
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PAN Bad Actor Chemical |
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Not applicable |
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Not applicable |
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Not applicable |
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Not applicable |
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White crystalline, odourless solid with a bitter taste |
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178 |
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470 |
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9.55 X 1000 |
Calculated |
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0.98 |
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Low |
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8.28 |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. |
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Soil adsorption and mobility |
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None
Terrestrial ecotoxicology |
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36.0 |
Lepomis macrochirus |
Moderate |
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HUMAN HEALTH AND PROTECTION |
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High (class III) |
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Carcinogen |
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Endocrine disruptor |
No data found |
A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data |
No data found |
Reproduction / development effects |
Acetyl cholinesterase inhibitor |
Neurotoxicant |
No data found |
No data found |
✓Yes, known to cause a problem |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
✓Yes, known to cause a problem |
✓Yes, known to cause a problem |
No data found |
Eye irritant |
Phototoxicant |
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✓Yes, known to cause a problem |
No data found |
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Highly toxic May cause nausea, vomiting, twitching and convulsions in large doses |
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When heated to decomposition it will emit toxic fumes of nitrogen oxides IMDG Transport Hazard Class 6.1 |
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Not listed (Not listed) |
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UN1570 |
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Packaging Group I (great danger) |
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brucine |
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Brucin |
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brucina |
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Record last updated: |
30/08/2024 |
Contact: |
aeru@herts.ac.uk |
Please cite as: |
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |