Prednisolone |
Last updated: 18/05/2024 |
(Also known as: D1-dehydrohydrocortisone; hydroretrocortine; meticortelone) |
|
|
A veterinary corticosteroid drug | |
---|---|---|
|
Current | |
|
- | |
|
Used for the control of inflammatory and allergic conditions such as asthma, rheumatoid arthritis and colitis | |
|
Dogs; Dogs; Cattle; Bears; Horses |
Approval status |
|
Approved | |
---|---|---|
|
Approved |
Chemical structure |
|
Isomeric | |
---|---|---|
|
C₂₁H₂₈O₅ | |
|
CC12CC(C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C)O | |
|
C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C)O | |
|
OIGNJSKKLXVSLS-VWUMJDOOSA-N | |
|
InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 | |
|
Yes |
|
Common Name | Relationship | Link |
---|---|---|
prednisolone | - |
General status |
|
Immunosuppressant, Anti-inflammatory, Medicinal drug | |
---|---|---|
|
Synthetic glucocorticoid | |
|
- | |
|
- | |
|
Synthetic | |
|
Irreversibly binds with glucocorticoid receptors (GR) alpha and beta | |
|
[Glucocorticoid receptor, Agonist] | |
|
50-24-8 | |
|
200-021-7 | |
|
- | |
|
- | |
|
- | |
|
Sensory organs: Otologicals; Antiinfectants for systemic use: Antibacterials for intramammary use | |
|
QS02CA01; QJ51RV01 | |
|
No | |
|
Allowed substance (Table 1: Bovine) | |
|
360.44 | |
|
- | |
|
(11β)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione | |
|
11,17-dihydroxy-17- (2-hydroxyacetyl)- 10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17- dodecahydrocyclopenta [a]phenanthren-3-one | |
|
- | |
|
- | |
|
White solid | |
|
Formulations |
|
|
|
|
|
||||||
---|---|---|---|---|---|---|---|---|---|---|
|
Canaural ear drops, suspension for dogs and cats | Dechra Veterinary Products A/S | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Dermipred 10 Tablets | Veva Animal Health Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Noroclav Intramammary Suspension for Lactating Cows | Norbrook Laboratories Ltd | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Prednicare Tablets 1 mg | Ecuphar NV | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
|
Available in a wide range of formulations including solutions for injection, cutaneous sprays and oral tablets, powders and gels |
|
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
223 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Moderate | ||||||||
|
33000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Ethanol3 = Unverified data of known source |
- | ||||||||
5500 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Chloroform3 = Unverified data of known source |
- | |||||||||
20000 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Acetone3 = Unverified data of known source |
- | |||||||||
|
235 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) with decomposition4 = Verified data |
- | ||||||||
|
Decomposes before boiling | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
- | ||||||||
|
240 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
- | ||||||||
|
- | - | - | ||||||||
|
|
4.17 X 1001 | Calculated | - | |||||||
|
1.62 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low | ||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
- | |||||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
In methanol: 242nm = 15000 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
- | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- |
Degradation |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | ||||||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
|
Stable | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Stable | |||||||
|
Not expected to hydrolyse | ||||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
|
- |
Soil adsorption and mobility |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
|
- | V1 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 1 = Estimated data with little or no verification |
Moderately mobile | |||||||
|
180 | ||||||||||
|
Estimated | ||||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
- | ||||||||||
|
- | ||||||||||
|
- |
Fate indices |
|
|
|
|
||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
- | - | - | ||||||||||||||||||||||||||
|
|
- | - | - | |||||||||||||||||||||||||
|
- | - |
Known soil and groundwater metabolites |
None
Other known metabolites |
|
|
|
|
||||
---|---|---|---|---|---|---|---|
prednisolone gluconoride | - | Animal (Liver) | - | ||||
prednisolone sulphate | - | Animal (Liver) | - |
|
Terrestrial ecotoxicology |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
1680 | E3 E = Manufacturers safety data sheets Mouse3 = Unverified data of known source |
Moderate | ||||||||
|
|
- | - | - | |||||||
|
- | - | |||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
- | - | - | |||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
- | |||||||||||
|
- | - | - | ||||||||
- | |||||||||||
|
|
- | - | - | |||||||
|
- | - | - | ||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
|
- | - | - | |||||||
|
- | ||||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - |
Aquatic ecotoxicology |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
85 | R4 R = Peer reviewed scientific publications Daphnia magna4 = Verified data |
Low | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
160 | R4 R = Peer reviewed scientific publications Pseudokirchneriella subcapitata4 = Verified data |
Low | ||||||||
|
|
- | - | - |
|
- | - | - |
|
General |
|
|
|
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
High (class III) | - | - | ||||||||
|
1680 | E3 E = Manufacturers safety data sheets Mouse3 = Unverified data of known source |
Moderate | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
Subcutaneous LD₅₀ = 147 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
- | ||||||||
Intraperitoneal LD₅₀ > 2000 mg kg⁻¹ | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) Rat3 = Unverified data of known source |
- | |||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
- | - | - | ||||||||
|
|
- | |||||||||
|
- | ||||||||||
|
In dairy cows prednisolone is mainly excreted via milk during milking. In other animals it is metabolised in the liver and excreted in the urine as both metabolites and the unchanged substance | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
- |
Health issues |
|
|
||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
IARC Group 3 carcinogen - not classifiable May cause fluid retention, acne, constipation, and mood swings Toxic to lungs and mucous membranes Osteoporosis is a possible side effect of long term treatment |
Handling issues |
|
|
|||
---|---|---|---|---|
|
Risk of explosion if present during electrical/static discharge | |||
|
- | |||
|
Not listed (Not listed) | |||
|
- | |||
|
- | |||
|
- |
|
|
|
||
---|---|---|---|
|
prednisolone | ||
|
- | ||
|
- | ||
|
- | ||
|
- | ||
|
prednisolona | ||
|
- | ||
|
- | ||
|
- | ||
|
- | ||
|
- | ||
|
- |
Record last updated: | 18/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |