Methylprednisolone |
Last updated: 22/01/2024 |
(Also known as: methyleneprednisolone) |
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A potent anti-inflammatory steroid used to manage inflammatory and allergic conditions, sometimes used as the acetate | |
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Current | |
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Used in the treatment of respiratory diseases and urogenital infections | |
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Dogs; Cats; Cattle; Horses |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₂₂H₃₀O₅ | |
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CC1CC2C3CCC(C3(CC(C2C4(C1=CC(=O)C=C4)C)O)C)(C(=O)CO)O | |
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C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)C=C4)C)O)C)(C(=O)CO)O | |
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VHRSUDSXCMQTMA-PJHHCJLFSA-N | |
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InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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methylprednisolone | - |
General status |
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Anti-inflammatory, Medicinal drug | |
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Corticosteroid | |
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Synthetic | |
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Suppresses immune system activity | |
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[Glucocorticoid receptor, Agonist] | |
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83-43-2 | |
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201-476-4 | |
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Systemic Hormonal Preparations, Excl. Sex Hormones & Insulins: Corticosteroids for systemic use | |
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QH02AB04 | |
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No | |
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Allowed substance (Table 1: Bovine) | |
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374.47 | |
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(1S,2R,8S,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one | |
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(6α, 11β)-11,17,21-trihydroxy-6-methyl-pregna-1,4-diene-3,20-dione | |
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White crystalline powder | |
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Formulations |
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Medrone V Tablets | Zoetis UK Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Solu-Medrone Powder & Solvent for Injection Solution | Zoetis UK Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Often formulated as solutions for injection and tablets for oral administration |
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120 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Moderate | ||||||||
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233 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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6.31 X 1001 | Calculated | - | |||||||
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1.8 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Low risk | Q3 Q = Miscellaneous data from online sources Based on LogP < 33 = Unverified data of known source |
Low risk | |||||||||||||||||||||||||
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Known soil and groundwater metabolites |
None
Other known metabolites |
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methylprednisolone-17-propionate | - | Human | - | ||||
hydroxymethylprednisolone | - | Human (Liver) | - |
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Terrestrial ecotoxicology |
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> 2000 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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> 2000 | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
Low | ||||||||
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Intraperitoneal LD₅₀ = 1000 mg kg⁻¹ | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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Subcutaneous LD₅₀ > 3000 mg kg⁻¹ | E3 E = Manufacturers safety data sheets Rat3 = Unverified data of known source |
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0.00016 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat4 = Verified data |
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Metabolised primarily by the liver and excreted by the kidneys. Small amounts of unmetabolized drug are excreted in urine and bile | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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May induce changes in metabolism May cause glaucoma, osteoporosis and psychosis May cause gastrointestinal problems |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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methylprednisolone | ||
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metilprednisolona | ||
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Record last updated: | 22/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |