Prednisolone acetate |
Last updated: 22/05/2024 |
(Also known as: prednisone 21-acetate) |
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A veterinary corticosteroid drug | |
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Current | |
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Used for the control of inflammatory and allergic conditions such as asthma, rheumatoid arthritis and colitis | |
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Dogs; Dogs; Cattle; Bears; Horses |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₂₃H₂₈O₆ | |
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CC(=O)OCC(=O)C1(CCC2C1(CC(=O)C3C2CCC4=CC(=O)C=CC34C)C)O | |
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CC(=O)OCC(=O)[C@]1(CC[C@@H]2[C@@]1(CC(=O)[C@H]3[C@H]2CCC4=CC(=O)C=C[C@]34C)C)O | |
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MOVRKLZUVNCBIP-RFZYENFJSA-N | |
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InChI=1S/C23H28O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h6,8,10,16-17,20,28H,4-5,7,9,11-12H2,1-3H3/t16-,17-,20+,21-,22-,23-/m0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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prednisolone acetate | - | |
prednisolone | Parent |
General status |
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Immunosuppressant, Anti-inflammatory, Medicinal drug | |
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Synthetic glucocorticoid | |
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Synthetic | |
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Irreversibly binds with glucocorticoid receptors (GR) alpha and beta | |
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[Glucocorticoid receptor, Agonist] | |
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125-10-0 | |
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204-726-0 | |
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91438 | |
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Sensory organs: Otologicals; Antiinfectants for systemic use: Antibacterials for intramammary use | |
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QS02CA01; QJ51RV01 | |
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No | |
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Allowed substance (Table 1: Bovine) | |
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400.5 | |
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[2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate | |
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Formulations |
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Aurimic ear drops, suspension for dogs and cats | VetViva Richter GmbH | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Cortico Vveyxin 10 Suspension for Injection | Veyx-Pharma GmbH | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
Surolan Ear Drops and Cutaneous Suspension | Elanco Europe Ltd | UK National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Available in a wide range of formulations including solutions for injection, cutaneous sprays and oral tablets, powders and gels |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
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Terrestrial ecotoxicology |
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1680 | E3 E = Manufacturers safety data sheets Mouse3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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1680 | E3 E = Manufacturers safety data sheets Mouse3 = Unverified data of known source |
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In dairy cows prednisolone is mainly excreted via milk during milking. In other animals it is metabolised in the liver and excreted in the urine as both metabolites and the unchanged substance | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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IARC Group 3 carcinogen - not classifiable May cause fluid retention, acne, constipation, and mood swings Toxic to lungs and mucous membranes Osteoporosis is a possible side effect of long term treatment |
Handling issues |
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Risk of explosion if present during electrical/static discharge | |||
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Not listed (Not listed) | |||
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prednisolone acetate | ||
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Record last updated: | 22/05/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |