Anabasine |
Last updated: 13/05/2024
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(Also known as: neonicotine; S-(-)-anabasine ) |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate |
Ecotoxicity |
Human health |
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A naturally occurring pyridine alkaloid insecticide which is now largely obsolete. |
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Aphids; Whiteflies |
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Considered obsolete but may be available in some countries |
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1929, first described; 1931 isolated; 1936, first synthesis |
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Not approved |
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Not applicable |
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No UK approval for use |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved |
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Not applicable |
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Not applicable |
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Not applicable |
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No |
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ATAustria |
BEBelgium |
BGBulgaria |
CYCyprus |
CZCzech Republic |
DEGermany |
DKDenmark |
EEEstonia |
ELGreece |
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ESSpain |
FIFinland |
FRFrance |
HRCroatia |
HUHungary |
IEIreland |
ITItaly |
LTLithuania |
LULuxembourg |
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LVLatvia |
MTMalta |
NLNetherlands |
PLPoland |
PTPortugal |
RORomania |
SESweden |
SISlovenia |
SKSlovakia |
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ISIceland |
NONorway |
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A chiral molecule. It is a structural isomer of, and chemically similar to, nicotine |
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C₁₀H₁₄N₂ |
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C1CCNC(C1)C2=CN=CC=C2 |
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C1CCN[C@@H](C1)C2=CN=CC=C2 |
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MTXSIJUGVMTTMU-JTQLQIEISA-N |
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InChI=1S/C10H14N2/c1-2-7-12-10(5-1)9-4-3-6-11-8-9/h3-4,6,8,10,12H,1-2,5,7H2 |
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Yes |
Cambridge Crystallographic Data Centre diagrams |
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Common Name |
Relationship |
Link |
(S)-(-)-Anabasine hydrochloride |
Variant |
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Insecticide |
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Plant-derived substance |
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Natural |
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Acetylcholinesterase (AChE) inhibitor. |
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A botanical pyridine alkaloid similar to nicotine that is found in the shoots of Anabasis aphylla and in the tree tobacco (Nicotiana glauca) plant |
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Extracted industrially from plants or synthesised in a two step process using benzoic anhydride. N largely produced in Russia. It is no longer produced in Europe |
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Crop protection |
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Aphids; Whiteflies |
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494-52-0 |
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207-791-3 |
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006001 |
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205586 |
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162.23 |
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- |
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(S)-3-(2-piperidyl)pyridine |
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3-(2S)-2-piperidinylpyridine |
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- |
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- |
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Not applicable |
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Not applicable |
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Not known |
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Not applicable |
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- |
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Colourless liquid |
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None identified |
None identified |
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1000000 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
High |
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9 |
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270 |
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9.33 X 1000 |
Calculated |
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0.97 |
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Low |
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1.046 |
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11.0 |
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400 |
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Highly volatile. If applied directly to plants or soil, drift is a concern & mitigation is advisable |
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2.8 |
R4 R = Peer reviewed scientific publications 4 = Verified data |
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Mustard leaves, n=1 |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. |
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Soil adsorption and mobility |
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Moderately mobile |
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80 |
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Estimated |
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Known soil and groundwater metabolites |
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None
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1-N-hydroxyanabasine |
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Mammals |
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Terrestrial ecotoxicology |
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HUMAN HEALTH AND PROTECTION |
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High (class III) |
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Intravenous LD₅₀ = 1.62 mg kg⁻¹ |
Mouse |
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Subcutaneous LD₅₀ = 22.0 mg kg⁻¹ |
Guinea pig |
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Very toxic in contact with skin or if swallowed |
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Carcinogen |
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Endocrine disruptor |
No data found |
A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative |
No data found |
Reproduction / development effects |
Acetyl cholinesterase inhibitor |
Neurotoxicant |
?Possibly, status not identified |
XNo, known not to cause a problem |
✓Yes, known to cause a problem |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
✓Yes, known to cause a problem |
✓Yes, known to cause a problem |
No data found |
Eye irritant |
Phototoxicant |
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✓Yes, known to cause a problem |
No data found |
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Ingestion may cause a variety of symptoms including increased salivation, vertigo, confusion, disturbed vision and hearing, photophobia, cold extremities, nausea, vomiting, diarrhoea, syncope and colonic spasms |
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May emit toxic fumes if heated Use water spray, dry chemical, carbon dioxide or chemical foams to fight fires IMDG Transport Hazard Class 6.1 |
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Not listed (Not listed) |
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UN3140 |
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Packaging Group I (great danger) |
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anabasine |
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anabasine |
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Record last updated: |
13/05/2024 |
Contact: |
aeru@herts.ac.uk |
Please cite as: |
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |