Difloxacin |
Last updated: 08/01/2024 |
(Not known by any other names) |
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Drug which has activity against some gram-positive and gram-negative bacilli and cocci including klebsiella, pseudomonas and salmonella | |
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Used mainly to treat certain bacterial infections, particularly skin infections, wounds, and pneumonia | |
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Cats; Dogs; Poultry; Cattle |
Approval status |
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Not approved | |
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Not approved |
Chemical structure |
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C₂₁H₁₉F₂N₃O₃ | |
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CN1CCN(CC1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=CC=C(C=C4)F)F | |
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NOCJXYPHIIZEHN-UHFFFAOYSA-N | |
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InChI=1S/C21H19F2N3O3/c1-24-6-8-25(9-7-24)19-11-18-15(10-17(19)23)20(27)16(21(28)29)12-26(18)14-4-2-13(22)3-5-14/h2-5,10-12H,6-9H2,1H3,(H,28,29) | |
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Yes |
General status |
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Antibiotic, Antibacterial, Antimicrobial, Medicinal drug | |
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Fluoroquinolone | |
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Synthetic | |
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Broad spectrum substance that inhibits bacterial enzymes, resulting in death of the bacteria | |
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[DNA gyrase subunit A, Antagonist] | |
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98106-17-3 | |
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Antiinfectants for systemic use: Antibacterials for systemic use | |
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QJ01MA94 | |
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No | |
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Allowed substance (Table 1: All food producing species) | |
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399.39 | |
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6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)- 4-oxoquinoline-3-carboxylic acid | |
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Annex 1 of EC Directive 2377/90 | |
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Formulations |
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Dicural 100mg Coated Tablets for Dogs | Forte Dodge Animal Health Holland | Not licensed | Not licensed | ||||||
Dicural 150mg Coated Tablets for Dogs | Forte Dodge Animal Health Holland | Not licensed | Not licensed | |||||||
Dicural 50mg/ml solution for injection for cattle and dogs | Forte Dodge Animal Health Holland | Not licensed | Not licensed | |||||||
Dicural 100mg/ml oral solution for chickens and turkeys | Forte Dodge Animal Health Holland | Not licensed | Not licensed | |||||||
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1330 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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7.76 X 1000 | Calculated | - | |||||||
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0.89 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
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2.99 X 10-09 | V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source |
Low volatility | ||||||||
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Soil adsorption and mobility |
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Fate indices |
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Known soil and groundwater metabolites |
None
Other known metabolites |
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N-desmethyldifloxacin | - | Animal | - | ||||
difloxacin-N-oxide | - | Animal | - |
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Terrestrial ecotoxicology |
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Aquatic ecotoxicology |
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General |
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High (class III) | - | - | ||||||||
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Excreted mainly in the faeces (~85-95%) and remainder in the urine | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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No further information available |
Handling issues |
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No information available | |||
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Not listed (Not listed) | |||
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difloxacin | ||
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Record last updated: | 08/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |